Jian-Ke Jia , Jun Yang , Xing-Zhi Yang , Ji-Feng Luo , Xiao-Yan Duan , Ying-Li Yang , Jin-Fu Wan , Yue-Hu Wang
{"title":"巴黎根茎中的细胞毒性甾体苷","authors":"Jian-Ke Jia , Jun Yang , Xing-Zhi Yang , Ji-Feng Luo , Xiao-Yan Duan , Ying-Li Yang , Jin-Fu Wan , Yue-Hu Wang","doi":"10.1016/j.phytol.2024.07.011","DOIUrl":null,"url":null,"abstract":"<div><p>Two previously undescribed steroidal saponins, rugosarosides A (<strong>1</strong>) and B (<strong>2</strong>), as well as 16 known compounds (<strong>3–18</strong>), were isolated from the rhizomes of <em>Paris rugosa</em> H. Li & S. Kurita (Melanthiaceae). Their chemical structures were elucidated based on extensive analyses of NMR and MS data and acidic hydrolyses. These isolates were evaluated for their cytotoxicity to five human cancer cell lines (HL-60, SW480, MDA-MB-231, A549, and A549/Taxol) and the normal human bronchial epithelial cell line BEAS-2B using the MTS test. Spirostanol saponins <strong>6</strong>–<strong>12</strong> and furostanol saponin <strong>16</strong> showed cytotoxic activity, with IC<sub>50</sub> values ranging from 0.13 to 3.88 <em>μ</em>M. The furostanol saponins <strong>14</strong>, <strong>15</strong>, and <strong>17</strong> selectively inhibited HL-60, A549, and A549/Taxol cells (IC<sub>50</sub>: 3.45–9.51 <em>μ</em>M), with no cytotoxicity to SW480 and MDA-MB-231 cells (IC<sub>50</sub> > 40 <em>μ</em>M).</p></div>","PeriodicalId":20408,"journal":{"name":"Phytochemistry Letters","volume":"63 ","pages":"Pages 1-7"},"PeriodicalIF":1.3000,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Cytotoxic steroidal glycosides from Paris rugosa rhizomes\",\"authors\":\"Jian-Ke Jia , Jun Yang , Xing-Zhi Yang , Ji-Feng Luo , Xiao-Yan Duan , Ying-Li Yang , Jin-Fu Wan , Yue-Hu Wang\",\"doi\":\"10.1016/j.phytol.2024.07.011\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Two previously undescribed steroidal saponins, rugosarosides A (<strong>1</strong>) and B (<strong>2</strong>), as well as 16 known compounds (<strong>3–18</strong>), were isolated from the rhizomes of <em>Paris rugosa</em> H. Li & S. Kurita (Melanthiaceae). Their chemical structures were elucidated based on extensive analyses of NMR and MS data and acidic hydrolyses. These isolates were evaluated for their cytotoxicity to five human cancer cell lines (HL-60, SW480, MDA-MB-231, A549, and A549/Taxol) and the normal human bronchial epithelial cell line BEAS-2B using the MTS test. Spirostanol saponins <strong>6</strong>–<strong>12</strong> and furostanol saponin <strong>16</strong> showed cytotoxic activity, with IC<sub>50</sub> values ranging from 0.13 to 3.88 <em>μ</em>M. The furostanol saponins <strong>14</strong>, <strong>15</strong>, and <strong>17</strong> selectively inhibited HL-60, A549, and A549/Taxol cells (IC<sub>50</sub>: 3.45–9.51 <em>μ</em>M), with no cytotoxicity to SW480 and MDA-MB-231 cells (IC<sub>50</sub> > 40 <em>μ</em>M).</p></div>\",\"PeriodicalId\":20408,\"journal\":{\"name\":\"Phytochemistry Letters\",\"volume\":\"63 \",\"pages\":\"Pages 1-7\"},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2024-07-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Phytochemistry Letters\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1874390024001101\",\"RegionNum\":4,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Phytochemistry Letters","FirstCategoryId":"99","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1874390024001101","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
Cytotoxic steroidal glycosides from Paris rugosa rhizomes
Two previously undescribed steroidal saponins, rugosarosides A (1) and B (2), as well as 16 known compounds (3–18), were isolated from the rhizomes of Paris rugosa H. Li & S. Kurita (Melanthiaceae). Their chemical structures were elucidated based on extensive analyses of NMR and MS data and acidic hydrolyses. These isolates were evaluated for their cytotoxicity to five human cancer cell lines (HL-60, SW480, MDA-MB-231, A549, and A549/Taxol) and the normal human bronchial epithelial cell line BEAS-2B using the MTS test. Spirostanol saponins 6–12 and furostanol saponin 16 showed cytotoxic activity, with IC50 values ranging from 0.13 to 3.88 μM. The furostanol saponins 14, 15, and 17 selectively inhibited HL-60, A549, and A549/Taxol cells (IC50: 3.45–9.51 μM), with no cytotoxicity to SW480 and MDA-MB-231 cells (IC50 > 40 μM).
期刊介绍：
Phytochemistry Letters invites rapid communications on all aspects of natural product research including:
• Structural elucidation of natural products
• Analytical evaluation of herbal medicines
• Clinical efficacy, safety and pharmacovigilance of herbal medicines
• Natural product biosynthesis
• Natural product synthesis and chemical modification
• Natural product metabolism
• Chemical ecology
• Biotechnology
• Bioassay-guided isolation
• Pharmacognosy
• Pharmacology of natural products
• Metabolomics
• Ethnobotany and traditional usage
• Genetics of natural products
Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.
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