磁性琼脂上固定化 Ag NPs（Fe3O4@Agar-Ag NPs）作为可重复使用的纳米生物催化剂的绿色合成及其对 MCF-7 癌细胞株的抑制作用

IF 2.2 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Journal of the Iranian Chemical Society Pub Date : 2024-08-06 DOI:10.1007/s13738-024-03066-y

Hamid Babavalian, Seyed Ali Moosavi, Fatemeh Shakeri, Mohammad Reza Khodabakhshi

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引用次数: 0

摘要

本研究以天然大分子（琼脂）为基础，利用廉价、无毒、易得的物质，通过简便的方法设计并制备了磁性生物相容性 Fe3O4@Agar-Ag 催化剂。合成完成后，催化剂通过各种技术（如傅立叶变换红外光谱、XRD、FE-SEM、EDX、VSM、TGA 和 ICP）进行了表征。随后，对其治疗乳腺癌的功效进行了体外评估。结果表明，该催化剂能有效减少 MCF-7 细胞的增殖，这表明它具有作为抗癌剂的潜力。此外，我们的研究结果还强调了合成纳米粒子的生物相容性及其对正常细胞的低毒性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Green synthesis of immobilized Ag NPs on the magnetic agar (Fe3O4@Agar-Ag NPs) as reusable nanobiocatalyst and its inhibitory effect on the MCF-7 cancerous cell lines

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Green synthesis of immobilized Ag NPs on the magnetic agar (Fe3O4@Agar-Ag NPs) as reusable nanobiocatalyst and its inhibitory effect on the MCF-7 cancerous cell lines

The magnetic biocompatible Fe₃O₄@Agar-Ag catalyst was designed and prepared based on a natural macromolecule (agar) through a convenient method using inexpensive, nontoxic, and easily available substances. Following synthesis, the catalyst underwent characterization using various techniques such as FT-IR, XRD, FE-SEM, EDX, VSM, TGA, and ICP. Subsequently, its efficacy was evaluated in treating breast cancer, in vitro. The results demonstrated the catalyst's effectiveness in reducing the proliferation of MCF-7 cells, suggesting its potential as an anticancer agent. Furthermore, our findings highlighted the biocompatibility of the synthesized nanoparticle and its lower toxicity toward normal cells.

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来源期刊

Journal of the Iranian Chemical Society 化学-化学综合

CiteScore

4.40

自引率

8.30%

发文量

230

审稿时长

5.6 months

期刊介绍： JICS is an international journal covering general fields of chemistry. JICS welcomes high quality original papers in English dealing with experimental, theoretical and applied research related to all branches of chemistry. These include the fields of analytical, inorganic, organic and physical chemistry as well as the chemical biology area. Review articles discussing specific areas of chemistry of current chemical or biological importance are also published. JICS ensures visibility of your research results to a worldwide audience in science. You are kindly invited to submit your manuscript to the Editor-in-Chief or Regional Editor. All contributions in the form of original papers or short communications will be peer reviewed and published free of charge after acceptance.