源自 2,3-二氨基吩嗪分子的席夫碱及其金属(II)配合物的抗结核、抗菌、抗氧化、细胞毒性和抗炎活性:结构阐释、计算方面和生物学评价

IF 4.1 3区 化学 Q1 CHEMISTRY, INORGANIC & NUCLEAR
Saleh M. Bufarwa, Reem M. El-Sefait, Dalal K. Thbayh, Mustapha Belaidi, Rehab K. Al-Shemary, Rema. M. Abdusamea, Marei M. El-Ajaily, Béla Fiser, Hanan A. Bader, Abdulsalam A. Saleh, Mohamad M. Bufarwa
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引用次数: 0

摘要

受传染性疾病现状的影响,研究人员从 6,6′-((1E-1′E)(酚嗪-2、3-二ielbis(azanylidene)-bis-(methanylidene)-bis-(3-(diethylamino)phenol))(H 2 L)合成的希夫碱配体,以确定其具有抗结核、抗炎、抗氧化、细胞毒性和抗菌活性。通过多种物理和光谱方法对有机配体及其金属(II)络合物进行了表征,结果表明这些络合物的通式为 [ML](其中 M = Co(II) (C1)、Ni(II) (C2)、Cu(II) (C3) 和 Cd(II) (C4))。针对肺结核、炎症和氧化剂的活性测试结果表明,所有化合物对这些症状都有显著的活性。此外,还评估了各种化合物对细菌和真菌菌株的有效性。具体来说,对四种细菌菌株(枯草杆菌、金黄色葡萄球菌、大肠杆菌和绿脓杆菌)和两种真菌菌株(黄曲霉和白色念珠菌)进行了测试,并与一些标准药物的结果进行了比较。结果显示,化合物 C4 对细菌菌株的疗效优于对比的标准药物。此外,还发现 C3 是对比抗生素中对真菌最有效的一种,而其他化合物则显示出中等程度的抗真菌活性。此外,为了支持体外实验结果,还进行了一些计算研究,如分子对接研究、DFT、MESP 和 AMEDT,以确认有机配体及其复合物对结核病的有效性。这些研究表明,C4 对结核病最有效,而且具有吸收、不降解、无肝毒性等理想效果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Antituberculosis, antimicrobial, antioxidant, cytotoxicity and anti-inflammatory activity of Schiff base derived from 2,3-diaminophenazine moiety and its metal(II) complexes: structural elucidation, computational aspects, and biological evaluation
Enticed by the present scenario of infectious diseases, four new Co(II), Ni(II), Cu(II), and Cd(II) complexes of Schiff base ligand were synthesized from 6,6′-((1E-1′E)(phenazine-2,3-dielbis(azanylidene)-bis-(methanylidene)-bis-(3-(diethylamino)phenol)) (H 2 L) to ascertain as effective drug for antituberculosis, anti-inflammatory, antioxidant, cytotoxic and antimicrobial activities. The organic ligand and its metal(II) complexes were characterized by numerous physical and spectroscopic methods, which showed that the complexes have a general formula, [ML], (where M = Co(II) (C1), Ni(II) (C2), Cu(II) (C3) and Cd(II) (C4)), for metal complexes have been proposed and have a square planar geometry, are amorphous in nature, and are thermally stable. Data highlight obtained from activity testing against tuberculosis, inflammation, and oxidants that all compounds are significantly active against these symptoms. Also, was to evaluate the effectiveness of various compounds against bacterial and fungal strains. Specifically, four bacterial strains (Bacillus subtilis, Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa) and two fungal strains (Aspergillus flavus and Candida albicans) were tested and compared to the results of some standard drugs. The results revealed that compound C4 was more effective against bacterial strains than the comparison standard drugs. In addition, C3 was found to be the most effective of the comparison antibiotics against fungi, while the other compounds showed moderate antifungal activity. Moreover, to support the vitro results, certain computational studies as molecular docking studies, DFT, MESP, and AMEDT were also conducted to confirm the effectiveness of an organic ligand and its complexes against tuberculosis. These studies revealed that C4 is the most effective against tuberculosis and has desirable effects such as absorption, no degradation and no hepatotoxicity, etc.
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来源期刊
Reviews in Inorganic Chemistry
Reviews in Inorganic Chemistry 化学-分析化学
CiteScore
7.30
自引率
4.90%
发文量
20
审稿时长
1 months
期刊介绍: Reviews in Inorganic Chemistry (REVIC) is a quarterly, peer-reviewed journal that focuses on developments in inorganic chemistry. Technical reviews offer detailed synthesis protocols, reviews of methodology and descriptions of apparatus. Topics are treated from a synthetic, theoretical, or analytical perspective. The editors and the publisher are committed to high quality standards and rapid handling of the review and publication process. The journal publishes all aspects of solid-state, molecular and surface chemistry. Topics may be treated from a synthetic, theoretical, or analytical perspective. The editors and the publisher are commited to high quality standards and rapid handling of the review and publication process. Topics: -Main group chemistry- Transition metal chemistry- Coordination chemistry- Organometallic chemistry- Catalysis- Bioinorganic chemistry- Supramolecular chemistry- Ionic liquids
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