利用反相纳米乳化技术封装亲水性物质的壳聚糖/二氧化硅杂化纳米凝胶

IF 4.2 3区 材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY
Asmaa M. Elzayat, Katharina Landfester, Rafael Muñoz‐Espí
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引用次数: 0

摘要

报告中介绍了一种壳聚糖/二氧化硅混合纳米水凝胶的制备方法,该方法将壳聚糖在纳米乳液体系中的凝胶化与生产二氧化硅的溶胶-凝胶工艺相结合。壳聚糖用作生物聚合物基质,而二氧化硅则用作结构添加剂。通过壳聚糖的阳离子基团与作为物理交联剂的三聚磷酸钠(STP)的阴离子基团之间的离子相互作用,获得水凝胶纳米胶囊。本研究比较了两种不同的制备方法:第一种方法是将 STP 加入壳聚糖反相乳液的连续相中;第二种方法是将分别含有壳聚糖和 STP 的两种乳液的液滴融合。所获得的纳米胶囊大小在 50 到 200 nm 之间。通过研究两种体系在中性水介质中的释放情况,考察了所形成的水凝胶夹带亲水性模型物质(麦角甘氨酸二钠盐)的效率。结果表明,两种制备方法都能有效地包裹亲水性物质,但液滴融合法产生的悬浮液更为稳定。一般观察结果表明,当体系中含有二氧化硅时,麦角苷的释放行为会明显减慢。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Chitosan/Silica Hybrid Nanogels by Inverse Nanoemulsion for Encapsulating Hydrophilic Substances
A strategy for the preparation of a hybrid chitosan/silica nanohydrogel is reported, which combines the gelation of chitosan in a nanoemulsion system with a sol–gel process to produce silica. Chitosan is used as a biopolymer matrix, while silica acts as a structuring additive. Hydrogel nanocapsules are obtained through the ionic interaction of the cationic groups of chitosan with the anionic groups of sodium triphosphate (STP), which is used as a physical cross‐linker. Two alternative preparation methods are compared in this work: in the first one, STP is added to the continuous phase of an inverse emulsion of chitosan; in the second one, the fusion of droplets of two emulsions containing separate chitosan and STP takes place. The size of the obtained nanocapsules ranges from 50 to 200 nm. The efficiency of the formed hydrogel for entrapping a hydrophilic model substance (erioglaucine disodium salt) is investigated for the two systems by studying the release in a neutral aqueous medium. The results indicate that the hydrophilic cargo is efficiently encapsulated by both preparation methods, although the droplet‐fusion method yields more stable suspensions. As a general observation, the release behavior of erioglaucine is systematically retarded when silica is present in the systems.
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来源期刊
Macromolecular Materials and Engineering
Macromolecular Materials and Engineering 工程技术-材料科学:综合
CiteScore
7.30
自引率
5.10%
发文量
328
审稿时长
1.6 months
期刊介绍: Macromolecular Materials and Engineering is the high-quality polymer science journal dedicated to the design, modification, characterization, processing and application of advanced polymeric materials, including membranes, sensors, sustainability, composites, fibers, foams, 3D printing, actuators as well as energy and electronic applications. Macromolecular Materials and Engineering is among the top journals publishing original research in polymer science. The journal presents strictly peer-reviewed Research Articles, Reviews, Perspectives and Comments. ISSN: 1438-7492 (print). 1439-2054 (online). Readership:Polymer scientists, chemists, physicists, materials scientists, engineers Abstracting and Indexing Information: CAS: Chemical Abstracts Service (ACS) CCR Database (Clarivate Analytics) Chemical Abstracts Service/SciFinder (ACS) Chemistry Server Reaction Center (Clarivate Analytics) ChemWeb (ChemIndustry.com) Chimica Database (Elsevier) COMPENDEX (Elsevier) Current Contents: Physical, Chemical & Earth Sciences (Clarivate Analytics) Directory of Open Access Journals (DOAJ) INSPEC (IET) Journal Citation Reports/Science Edition (Clarivate Analytics) Materials Science & Engineering Database (ProQuest) PASCAL Database (INIST/CNRS) Polymer Library (iSmithers RAPRA) Reaction Citation Index (Clarivate Analytics) Science Citation Index (Clarivate Analytics) Science Citation Index Expanded (Clarivate Analytics) SciTech Premium Collection (ProQuest) SCOPUS (Elsevier) Technology Collection (ProQuest) Web of Science (Clarivate Analytics)
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