使用金/石墨烯/Ti3C2Tx-MXene 混合层的高灵敏 PCF-SPR RI 癌症检测传感器

IF 3.3 4区 物理与天体物理 Q2 CHEMISTRY, PHYSICAL
Yimin Mao, Fang Ren, Deyang Zhou, Yidan Li
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引用次数: 0

摘要

本文提出了一种基于表面等离子体共振 (SPR) 传感器的金/石墨烯/Ti3C2Tx-MXene 混合层状 D 型光子晶体光纤 (PCF) 设计,用于癌细胞检测。该设计独特地结合了金、石墨烯和 Ti3C2Tx-MXene 材料,实现了协同效应,显著提高了传感器的灵敏度和特异性。全矢量有限元法(FVFEM)被用于拟议生物传感器的整个数值分析。D 型 PCF 的包层具有六边形排列的气孔。在第一层包层中,最靠近金属层的两个气孔被缩小,以增强等离子体波并提供有效的泄漏通道。同一层中最靠近金属层的最后两个气孔被扩大,以限制光散射,并将更多能量耦合到表面等离子体极化子(SPP)模式。通过使用这些不同直径的气孔,并在 D 型 PCF 表面镀上金/石墨烯/Ti3C2Tx-MXene 混合层,传感器的灵敏度得到了提高。为了获得更高的传感器灵敏度,对几何参数进行了优化。相应的波长灵敏度分别为:Basal 细胞 3000 nm/RIU;HeLa 细胞(Henrietta Lacks 细胞)5000 nm/RIU;Jurkat 细胞(人类 T 淋巴细胞)5714 nm/RIU;PC12 细胞(嗜铬细胞瘤细胞)7143 nm/RIU、MDA-MB-231 细胞(乳腺癌细胞)的 8571 nm/RIU,以及 MCF-7 细胞(密歇根癌症基金会-7,一种乳腺癌细胞系)的 9286 nm/RIU,证实了所提出传感器的卓越性能。所提出的传感器为高效、简单、低成本和高灵敏度的癌症检测技术铺平了道路,可以取代外科手术和化学技术。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Highly Sensitive PCF-SPR RI Sensor for Cancer Detection Using Gold/Graphene/Ti3C2Tx-MXene Hybrid Layer

Highly Sensitive PCF-SPR RI Sensor for Cancer Detection Using Gold/Graphene/Ti3C2Tx-MXene Hybrid Layer

In this paper, a gold/graphene/Ti3C2Tx-MXene hybrid layered D-type photonic crystal fiber (PCF) design based on surface plasmon resonance (SPR) sensors is proposed for cancer cell detection. This design uniquely combines gold, graphene, and Ti3C2Tx-MXene materials to achieve a synergistic effect, significantly enhancing the sensitivity and specificity of the sensor. The full vector finite element method (FVFEM) is used for the entire numerical analysis of the proposed biosensor. The cladding of the D-type PCF has a hexagonal arrangement of air holes. In the first cladding, the two air holes closest to the metal layer are narrowed down to enhance the plasma wave and provide an efficient leakage channel. The last two air holes closest to the metal layer in the same layer are enlarged to limit light scattering and couple more energy to the surface plasmon polariton (SPP) mode. The sensitivity of the sensor improves by using these different diameter air holes and coating the D-type PCF surface with a hybrid gold/graphene/Ti3C2Tx-MXene layer. The geometrical parameters are optimized to obtain higher sensor sensitivity. The corresponding wavelength sensitivities are 3000 nm/RIU for Basal cells, 5000 nm/RIU for HeLa cells (Henrietta Lacks cells), 5714 nm/RIU for Jurkat cells (Human T lymphocyte cells), 7143 nm/RIU for PC12 cells (Pheochromocytoma cells), 8571 nm/RIU for MDA-MB-231 cells (Breast cancer cells), and 9286 nm/RIU for MCF-7 cells (Michigan Cancer Foundation-7, a breast cancer cell line), respectively, confirming the excellent performance of the proposed sensor. The sensor proposed paves the way for efficient, simple, low-cost, and highly sensitive cancer detection techniques that could replace surgical and chemical techniques.

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来源期刊
Plasmonics
Plasmonics 工程技术-材料科学:综合
CiteScore
5.90
自引率
6.70%
发文量
164
审稿时长
2.1 months
期刊介绍: Plasmonics is an international forum for the publication of peer-reviewed leading-edge original articles that both advance and report our knowledge base and practice of the interactions of free-metal electrons, Plasmons. Topics covered include notable advances in the theory, Physics, and applications of surface plasmons in metals, to the rapidly emerging areas of nanotechnology, biophotonics, sensing, biochemistry and medicine. Topics, including the theory, synthesis and optical properties of noble metal nanostructures, patterned surfaces or materials, continuous or grated surfaces, devices, or wires for their multifarious applications are particularly welcome. Typical applications might include but are not limited to, surface enhanced spectroscopic properties, such as Raman scattering or fluorescence, as well developments in techniques such as surface plasmon resonance and near-field scanning optical microscopy.
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