三尖杉多酚概况及抗菌、抗丁酰胆碱酯酶、抗α-淀粉酶和杀幼虫剂活性的评估

IF 2.2 4区 化学 Q2 Engineering
Soumya Chebchoub, Zahia Kabouche, Djedjiga Bellouche, Ahmed Kabouche
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引用次数: 0

摘要

在这项研究中,我们采用 RP-UHPLC-ESI-QTOF-MS 技术研究了生长在阿尔及利亚的一种亚麻科药用植物 Linum trigynum L. (BELTr)的正丁醇馏分中的多酚成分,并评估了其抗菌、杀幼虫剂以及抑制 α 淀粉酶和丁酰胆碱酯酶 (BChE) 的潜力。在 BELTr 中鉴定出了 56 种多酚,其中主要的化合物是麦角苷-2 和荭草苷的异构体以及异麦角苷。提取物对 BChE 有明显的抑制作用(IC50:112.45 ± 3.93 µg/mL),对 α 淀粉酶有良好的抑制作用(IC50:2.25 ± 4.05 mg/mL)。此外,BFLTr 对大肠杆菌 ATCC 25922、金黄色葡萄球菌 ATCC 25923、金黄色葡萄球菌 ATCC 6538P、肠炎沙门氏菌 ATCC 13076、枯草芽孢杆菌 ATCC 6633、肺炎克雷伯氏菌 ATCC 6538P、肠炎沙门氏菌 ATCC 13076、枯草芽孢杆菌 ATCC 6633 和肺炎克雷伯氏菌 ATCC 6538P 都具有抗菌活性、肺炎克雷伯菌 ATCC 13883、粪肠球菌 ATCC 19433 和铜绿假单胞菌 ATCC 27853,以及酵母菌株白色念珠菌 ATCC 1031,其 MIC 值介于 250 至 500 µg/mL 之间,杀幼虫剂效果较弱。这种提取物的活性可能是由于它富含黄酮类化合物和酚酸,可以通过直接机制或协同机制发挥作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Polyphenolic profile and evaluation of the antimicrobial, antibutyrylcholinesterase, antialpha-amylase and larvicidal activities of Linum trigynum L.

Polyphenolic profile and evaluation of the antimicrobial, antibutyrylcholinesterase, antialpha-amylase and larvicidal activities of Linum trigynum L.

In this study, we investigated the polyphenolic composition of the n-butanol fraction of Linum trigynum L. (BELTr), a medicinal plant from the Linaceae family that grows in Algeria, using RP–UHPLC–ESI–QTOF–MS technique and evaluated of its antimicrobial, larvicidal and inhibition of α-amylase and butyrylcholinesterase (BChE) potentials. Fifty-six polyphenols were identified in the BELTr with isomers of vicenin-2 and orientin, and isovitexin as the major compounds. The extract showed a significant inhibition of BChE (IC50: 112.45 ± 3.93 µg/mL) and a good inhibition of α-amylase (IC50: 2.25 ± 4.05 mg/mL). In addition, the BFLTr exhibited antimicrobial activity against Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 25923, Staphylococcus aureus ATCC 6538P, Salmonella enterica ATCC 13076, Bacillus subtilis ATCC 6633, Klebsiella pneumoniae ATCC 13883, Enterococcus faecalis ATCC 19433 and Pseudomonas aeruginosa ATCC 27853, as well as a yeast strain, Candida albicans ATCC 1031, with MICs values ranging between 250 and 500 µg/mL and a weak larvicidal effect. The extract’s activities may be attributed to its richness in flavonoids and phenolic acids, either through a direct mechanism or in a synergistic one.

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来源期刊
Chemical Papers
Chemical Papers Chemical Engineering-General Chemical Engineering
CiteScore
3.30
自引率
4.50%
发文量
590
期刊介绍: Chemical Papers is a peer-reviewed, international journal devoted to basic and applied chemical research. It has a broad scope covering the chemical sciences, but favors interdisciplinary research and studies that bring chemistry together with other disciplines.
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