生长在阿尔及利亚撒哈拉沙漠的 Cotula cinerea 的化学成分、抗糖尿病、抗氧化和抗炎潜力

IF 2.2 4区 化学 Q2 Engineering
Nour Elhouda Mekhadmi, Assia Bentahar, Randa Mlik, Safia Ben Amor, Asma Abid, Walid Bousabaa, Aicha Mouane, Amara Djilani Ghemam, Houria Ben Neser, Messaoud Ramdani, Ammar AL-Farga, Messaoudi Mohammed
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引用次数: 0

摘要

我们的研究旨在考察 Cotula cinerea 的植物化学成分和生物特征,这是一种在阿尔及利亚撒哈拉地区发现的本地植物。Cotula cinerea 的提取物采用水浸法提取,提取物中含有高浓度的多酚(34.01 ± 1.08 毫克 GAE/克)和黄酮类化合物(24.10 ± 0.82 毫克 EQ/克)。对大鼠进行的毒性研究表明,该提取物不会产生有害影响,从而证实了其安全性。值得注意的是,使用 C. cinerea 提取物在降低血糖水平方面效果显著。接受提取物治疗的糖尿病大鼠的血糖水平(D500 = 1.04 ± 0.13 g/l)比未接受治疗的大鼠(2.92 ± 0.23 g/l)明显降低。此外,接受治疗的糖尿病大鼠的所有其他生化指标均与对照组相当或优于对照组。通过 DPPH(IC50 = 0.54 ± 0.023 mg/ml)和 FRAP(IC50 = 0.51 ± 0.012 mg/ml)测试,体外试验验证了提取物的抗氧化能力。抗坏血酸被用作参考,其浓度分别为 0.06 ± 0.005 mg/ml 和 0.11 ± 0.014 mg/ml。此外,还对该植物的抗炎特性进行了体外和体内评估。其功效按以下顺序排列:效力从高到低的顺序如下:阿司匹林、双氯芬酸、提取物(500 毫克/千克体重)、提取物(250 毫克/千克体重)。研究结果表明,C. cinerea 是一种很有潜力的生物活性化学物质,具有显著的降血糖、抗氧化和抗炎活性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Chemical composition, anti-diabetic, antioxidant, and anti-inflammatory potentials of Cotula cinerea growing in Algerian Sahara

Chemical composition, anti-diabetic, antioxidant, and anti-inflammatory potentials of Cotula cinerea growing in Algerian Sahara

Chemical composition, anti-diabetic, antioxidant, and anti-inflammatory potentials of Cotula cinerea growing in Algerian Sahara

Our study aimed to examine the phytochemical composition and biological features of Cotula cinerea, an indigenous plant found in the Algerian Sahara. The aqueous maceration process was used to get the extract of Cotula cinerea, which showed a high concentration of polyphenols (34.01 ± 1.08 mg GAE/g) and flavonoids (24.10 ± 0.82 mg EQ/g). The toxicity studies on rats demonstrated no detrimental effects, confirming the extract’s safety. Notably, the use of C. cinerea extract showed significant results in lowering blood sugar levels. The diabetic rats that received the extract showed significantly reduced glucose levels (D500 = 1.04 ± 0.13 g/l) compared to those without treatment (2.92 ± 0.23 g/l). In addition, all other biochemical parameters in the diabetic rats who received treatment were comparable to or superior to those of the control group. The extract’s antioxidant capacity was verified through in vitro testing utilizing DPPH (IC50 = 0.54 ± 0.023 mg/ml) and FRAP (IC50 = 0.51 ± 0.012 mg/ml) tests. Ascorbic acid was used as a reference, with concentrations of 0.06 ± 0.005 mg/ml and 0.11 ± 0.014 mg/ml for the respective assays. Moreover, the plant's anti-inflammatory properties were assessed both in vitro and in vivo. Its effectiveness was ranked in the following order: The order of effectiveness, from highest to lowest, is as follows: Aspirin, Diclofenac, Extract (500 mg/kg b.w.), Extract (250 mg/kg b.w.). The findings emphasize the potential of C. cinerea as a promising reservoir of bioactive chemicals with notable hypoglycemic, antioxidant, and anti-inflammatory activities.

Graphical abstract

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来源期刊
Chemical Papers
Chemical Papers Chemical Engineering-General Chemical Engineering
CiteScore
3.30
自引率
4.50%
发文量
590
期刊介绍: Chemical Papers is a peer-reviewed, international journal devoted to basic and applied chemical research. It has a broad scope covering the chemical sciences, but favors interdisciplinary research and studies that bring chemistry together with other disciplines.
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