Nour Elhouda Mekhadmi, Assia Bentahar, Randa Mlik, Safia Ben Amor, Asma Abid, Walid Bousabaa, Aicha Mouane, Amara Djilani Ghemam, Houria Ben Neser, Messaoud Ramdani, Ammar AL-Farga, Messaoudi Mohammed
{"title":"生长在阿尔及利亚撒哈拉沙漠的 Cotula cinerea 的化学成分、抗糖尿病、抗氧化和抗炎潜力","authors":"Nour Elhouda Mekhadmi, Assia Bentahar, Randa Mlik, Safia Ben Amor, Asma Abid, Walid Bousabaa, Aicha Mouane, Amara Djilani Ghemam, Houria Ben Neser, Messaoud Ramdani, Ammar AL-Farga, Messaoudi Mohammed","doi":"10.1007/s11696-024-03585-1","DOIUrl":null,"url":null,"abstract":"<div><p>Our study aimed to examine the phytochemical composition and biological features of <i>Cotula cinerea</i>, an indigenous plant found in the Algerian Sahara. The aqueous maceration process was used to get the extract of <i>Cotula cinerea</i>, which showed a high concentration of polyphenols (34.01 ± 1.08 mg GAE/g) and flavonoids (24.10 ± 0.82 mg EQ/g). The toxicity studies on rats demonstrated no detrimental effects, confirming the extract’s safety. Notably, the use of <i>C. cinerea</i> extract showed significant results in lowering blood sugar levels. The diabetic rats that received the extract showed significantly reduced glucose levels (D500 = 1.04 ± 0.13 g/l) compared to those without treatment (2.92 ± 0.23 g/l). In addition, all other biochemical parameters in the diabetic rats who received treatment were comparable to or superior to those of the control group. The extract’s antioxidant capacity was verified through in vitro testing utilizing DPPH (IC<sub>50</sub> = 0.54 ± 0.023 mg/ml) and FRAP (IC<sub>50</sub> = 0.51 ± 0.012 mg/ml) tests. Ascorbic acid was used as a reference, with concentrations of 0.06 ± 0.005 mg/ml and 0.11 ± 0.014 mg/ml for the respective assays. Moreover, the plant's anti-inflammatory properties were assessed both in vitro and in vivo. Its effectiveness was ranked in the following order: The order of effectiveness, from highest to lowest, is as follows: Aspirin, Diclofenac, Extract (500 mg/kg b.w.), Extract (250 mg/kg b.w.). The findings emphasize the potential of <i>C. cinerea</i> as a promising reservoir of bioactive chemicals with notable hypoglycemic, antioxidant, and anti-inflammatory activities.</p><h3>Graphical abstract</h3>\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":513,"journal":{"name":"Chemical Papers","volume":null,"pages":null},"PeriodicalIF":2.2000,"publicationDate":"2024-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Chemical composition, anti-diabetic, antioxidant, and anti-inflammatory potentials of Cotula cinerea growing in Algerian Sahara\",\"authors\":\"Nour Elhouda Mekhadmi, Assia Bentahar, Randa Mlik, Safia Ben Amor, Asma Abid, Walid Bousabaa, Aicha Mouane, Amara Djilani Ghemam, Houria Ben Neser, Messaoud Ramdani, Ammar AL-Farga, Messaoudi Mohammed\",\"doi\":\"10.1007/s11696-024-03585-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Our study aimed to examine the phytochemical composition and biological features of <i>Cotula cinerea</i>, an indigenous plant found in the Algerian Sahara. 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Ascorbic acid was used as a reference, with concentrations of 0.06 ± 0.005 mg/ml and 0.11 ± 0.014 mg/ml for the respective assays. Moreover, the plant's anti-inflammatory properties were assessed both in vitro and in vivo. Its effectiveness was ranked in the following order: The order of effectiveness, from highest to lowest, is as follows: Aspirin, Diclofenac, Extract (500 mg/kg b.w.), Extract (250 mg/kg b.w.). 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Chemical composition, anti-diabetic, antioxidant, and anti-inflammatory potentials of Cotula cinerea growing in Algerian Sahara
Our study aimed to examine the phytochemical composition and biological features of Cotula cinerea, an indigenous plant found in the Algerian Sahara. The aqueous maceration process was used to get the extract of Cotula cinerea, which showed a high concentration of polyphenols (34.01 ± 1.08 mg GAE/g) and flavonoids (24.10 ± 0.82 mg EQ/g). The toxicity studies on rats demonstrated no detrimental effects, confirming the extract’s safety. Notably, the use of C. cinerea extract showed significant results in lowering blood sugar levels. The diabetic rats that received the extract showed significantly reduced glucose levels (D500 = 1.04 ± 0.13 g/l) compared to those without treatment (2.92 ± 0.23 g/l). In addition, all other biochemical parameters in the diabetic rats who received treatment were comparable to or superior to those of the control group. The extract’s antioxidant capacity was verified through in vitro testing utilizing DPPH (IC50 = 0.54 ± 0.023 mg/ml) and FRAP (IC50 = 0.51 ± 0.012 mg/ml) tests. Ascorbic acid was used as a reference, with concentrations of 0.06 ± 0.005 mg/ml and 0.11 ± 0.014 mg/ml for the respective assays. Moreover, the plant's anti-inflammatory properties were assessed both in vitro and in vivo. Its effectiveness was ranked in the following order: The order of effectiveness, from highest to lowest, is as follows: Aspirin, Diclofenac, Extract (500 mg/kg b.w.), Extract (250 mg/kg b.w.). The findings emphasize the potential of C. cinerea as a promising reservoir of bioactive chemicals with notable hypoglycemic, antioxidant, and anti-inflammatory activities.
Chemical PapersChemical Engineering-General Chemical Engineering
CiteScore
3.30
自引率
4.50%
发文量
590
期刊介绍:
Chemical Papers is a peer-reviewed, international journal devoted to basic and applied chemical research. It has a broad scope covering the chemical sciences, but favors interdisciplinary research and studies that bring chemistry together with other disciplines.