基于网络的经颅直流电刺激可增强健康年轻人的注意力功能：一项初步研究

IF 2.4 3区医学 Q3 NEUROSCIENCES

Frontiers in Human Neuroscience Pub Date : 2024-08-08 DOI:10.3389/fnhum.2024.1421230

Xiaoyu Wei, Rong Zhou, Suwang Zheng, Yufeng Zhang, Xiaofan Feng, Jiaojiao Lü

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引用次数: 0

摘要

注意力是一个复杂的认知过程，与大脑背侧注意力网络（DAN）和默认网络（DN）的功能活动有关。本研究旨在调查经颅直流电刺激（tDCS）范式的可行性、安全性和盲法疗效，该范式旨在提高 DAN 的兴奋性，同时抑制 DN（DAN+/DN-tDCS），从而影响健康年轻人的注意力功能。在这项随机对照实验中，参与者被分配到 DAN+/DN-tDCS 组或假组。单次干预以 4 mA 的总强度进行，持续 20 分钟。参与者在刺激前后立即完成注意力网络测试（ANT）。40名参与者完成了研究，每组20人。配对样本 t 检验显示，DAN+/DN-tDCS 组的执行效果在刺激后有明显改善（t = 2.245; p = 0.037）。假组在 ANT 表现上没有任何明显差异。受试者识别刺激类型的准确率为 52.50%，这表明各组之间的盲化效果没有差异（p = 0.241）。DAN+/DN-tDCS组有轻度至中度不良反应，如刺痛、瘙痒和皮肤发红（p < 0.05）。这项研究提出了提高注意力表现的新策略，并鼓励进一步研究这些干预措施在不同人群中的作用机制和结果。

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Network-based transcranial direct current stimulation enhances attention function in healthy young adults: a preliminary study

Attention, a complex cognitive process, is linked to the functional activities of the brain’s dorsal attention network (DAN) and default network (DN). This study aimed to investigate the feasibility, safety, and blinding efficacy of a transcranial direct current stimulation (tDCS) paradigm designed to increase the excitability of the DAN while inhibiting the DN (DAN+/DN-tDCS) on attention function in healthy young adults.In this randomized controlled experiment, participants were assigned to either the DAN+/DN-tDCS group or the sham group. A single intervention session was conducted at a total intensity of 4 mA for 20 min. Participants completed the Attention Network Test (ANT) immediately before and after stimulation. Blinding efficacy and adverse effects were assessed post-stimulation.Forty participants completed the study, with 20 in each group. Paired-sample t-test showed a significant post-stimulation improvement in executive effect performance (t = 2.245; p = 0.037) in the DAN+/DN-tDCS group. The sham group did not exhibit any significant differences in ANT performance. Participants identified the stimulation type with 52.50% accuracy, indicating no difference in blinding efficacy between groups (p = 0.241). Mild-to-moderate adverse effects, such as stinging, itching, and skin reddening, were reported in the DAN+/DN-tDCS group (p < 0.05).DAN+/DN-tDCS enhanced attention function in healthy young individuals, particularly in improving executive effect performance. This study presents novel strategies for enhancing attentional performance and encourages further investigation into the mechanisms and outcomes of these interventions across diverse populations.

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来源期刊

Frontiers in Human Neuroscience 医学-神经科学

CiteScore

4.70

自引率

6.90%

发文量

830

审稿时长

2-4 weeks

期刊介绍： Frontiers in Human Neuroscience is a first-tier electronic journal devoted to understanding the brain mechanisms supporting cognitive and social behavior in humans, and how these mechanisms might be altered in disease states. The last 25 years have seen an explosive growth in both the methods and the theoretical constructs available to study the human brain. Advances in electrophysiological, neuroimaging, neuropsychological, psychophysical, neuropharmacological and computational approaches have provided key insights into the mechanisms of a broad range of human behaviors in both health and disease. Work in human neuroscience ranges from the cognitive domain, including areas such as memory, attention, language and perception to the social domain, with this last subject addressing topics, such as interpersonal interactions, social discourse and emotional regulation. How these processes unfold during development, mature in adulthood and often decline in aging, and how they are altered in a host of developmental, neurological and psychiatric disorders, has become increasingly amenable to human neuroscience research approaches. Work in human neuroscience has influenced many areas of inquiry ranging from social and cognitive psychology to economics, law and public policy. Accordingly, our journal will provide a forum for human research spanning all areas of human cognitive, social, developmental and translational neuroscience using any research approach.