新型聚（丙烯酸）-钙锌生物矿化水凝胶的抗菌和成骨特性评估

IF 2.6 4区材料科学 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY

Frontiers in Materials Pub Date : 2024-08-09 DOI:10.3389/fmats.2024.1444750

Xiaobin Xie, Xiaoxiao Feng, Lihui Hong, Xinke Yu, Hongye Li, Hao Zhang, Mingming Liu, Yimeng Wang

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引用次数: 0

摘要

感染性骨缺损是骨科医生面临的棘手问题之一。开发具有抗菌成骨功能的假体材料是一个关键的解决方案。基于聚丙烯酸（PAA）的可生物降解水凝胶因其卓越的品质而备受关注。然而，锌离子对基于 PAA 的矿化水凝胶的影响仍未得到充分研究。本文通过离子交联和生物矿化制备了聚（丙烯酸）-钙锌（PA-CZ）生物矿化水凝胶。体外细菌和细胞测试表明，该水凝胶具有优异的生物相容性、抗菌性、成骨性以及良好的机械强度。PA-CZ 矿化水凝胶为开发具有抗菌成骨特性的骨科植入物奠定了基础，并为治疗感染性骨缺损提供了一种前景广阔的方法。

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Evaluation of antibacterial and osteogenic properties of a novel Poly (acrylic acid)-calcium-zinc biomineralized hydrogel

Infectious bone defects are one of the thorny problems faced by orthopedists. Developing prosthetic materials with antimicrobial osteogenic features is a key solution. Biodegradable Polyacrylic acid (PAA)-based hydrogels have gained attention for their exceptional qualities. However, the influence of zinc ions on PAA-based mineralized hydrogels remains understudied. In this paper, Poly (acrylic acid)-calcium-zinc (PA-CZ) biomineralized hydrogel was prepared through ionic cross-linking and biomineralization. In vitro bacterial and cell tests demonstrated the hydrogel’s exceptional biocompatibility, antibacterial, and osteogenic traits, along with good mechanical strength. The PA-CZ mineralized hydrogel lays the foundation for developing orthopedic implants with antimicrobial osteogenic features and offers a promising approach for treating infected bone defects.

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来源期刊

Frontiers in Materials Materials Science-Materials Science (miscellaneous)

CiteScore

4.80

自引率

6.20%

发文量

749

审稿时长

12 weeks

期刊介绍： Frontiers in Materials is a high visibility journal publishing rigorously peer-reviewed research across the entire breadth of materials science and engineering. This interdisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers across academia and industry, and the public worldwide. Founded upon a research community driven approach, this Journal provides a balanced and comprehensive offering of Specialty Sections, each of which has a dedicated Editorial Board of leading experts in the respective field.