诺卡氏菌角膜炎:临床诊断与成功结果

Q3 Medicine
Oman Journal of Ophthalmology Pub Date : 2024-06-27 eCollection Date: 2024-05-01 DOI:10.4103/ojo.ojo_175_23
Dubbaka Srujana, Sandeep Shankar, Kavita Bala Anand, Mohini Agrawal, Aanchal Singhal, Ashok Kumar, Divya Kochhar
{"title":"诺卡氏菌角膜炎:临床诊断与成功结果","authors":"Dubbaka Srujana, Sandeep Shankar, Kavita Bala Anand, Mohini Agrawal, Aanchal Singhal, Ashok Kumar, Divya Kochhar","doi":"10.4103/ojo.ojo_175_23","DOIUrl":null,"url":null,"abstract":"<p><p><i>Nocardia</i> keratitis is mostly seen in patients with alcoholism, malnutrition, or HIV. Its chronic waxing-and-waning course makes it difficult to diagnose. A 53-year-old male presented with pain and redness in his right eye for the past 3 weeks. The cornea had paracentral ulcer with stromal infiltrates and multiple satellite lesions giving wreath-like appearance suggestive of <i>Nocardia</i>. After corneal scraping, fortified amikacin, moxifloxacin, and cycloplegics were started. Gram stain revealed filamentous, branching Gram-positive bacteria and acid-fast on Ziehl-Neelsen stain confirming our clinical diagnosis. Ulcer completely resolved over 6 weeks. Thus, a high index of clinical suspicion which was further backed by microbiological confirmation aided in expedient management ensuring a successful outcome.</p>","PeriodicalId":19461,"journal":{"name":"Oman Journal of Ophthalmology","volume":"17 2","pages":"261-263"},"PeriodicalIF":0.0000,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11309550/pdf/","citationCount":"0","resultStr":"{\"title\":\"<i>Nocardia</i> keratitis: A clinical diagnosis with successful outcome.\",\"authors\":\"Dubbaka Srujana, Sandeep Shankar, Kavita Bala Anand, Mohini Agrawal, Aanchal Singhal, Ashok Kumar, Divya Kochhar\",\"doi\":\"10.4103/ojo.ojo_175_23\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><i>Nocardia</i> keratitis is mostly seen in patients with alcoholism, malnutrition, or HIV. Its chronic waxing-and-waning course makes it difficult to diagnose. A 53-year-old male presented with pain and redness in his right eye for the past 3 weeks. The cornea had paracentral ulcer with stromal infiltrates and multiple satellite lesions giving wreath-like appearance suggestive of <i>Nocardia</i>. After corneal scraping, fortified amikacin, moxifloxacin, and cycloplegics were started. Gram stain revealed filamentous, branching Gram-positive bacteria and acid-fast on Ziehl-Neelsen stain confirming our clinical diagnosis. Ulcer completely resolved over 6 weeks. Thus, a high index of clinical suspicion which was further backed by microbiological confirmation aided in expedient management ensuring a successful outcome.</p>\",\"PeriodicalId\":19461,\"journal\":{\"name\":\"Oman Journal of Ophthalmology\",\"volume\":\"17 2\",\"pages\":\"261-263\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-06-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11309550/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Oman Journal of Ophthalmology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4103/ojo.ojo_175_23\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/5/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Oman Journal of Ophthalmology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/ojo.ojo_175_23","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/5/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0

摘要

诺卡氏角膜炎多见于酗酒、营养不良或感染艾滋病毒的患者。该病的病程呈慢性徘徊状态,因此很难诊断。一名 53 岁的男性患者在过去 3 周内出现右眼疼痛和发红。角膜中央旁有溃疡,基质浸润,多个卫星病变呈花环状,提示为诺卡菌感染。角膜刮除后,开始使用强化阿米卡星、莫西沙星和环磷酰胺。革兰氏染色显示为丝状、分支革兰氏阳性菌,Ziehl-Neelsen 染色显示为耐酸菌,证实了我们的临床诊断。溃疡在 6 周内完全消退。由此可见,高度的临床怀疑和微生物学证实有助于快速处理,确保了患者的成功。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Nocardia keratitis: A clinical diagnosis with successful outcome.

Nocardia keratitis is mostly seen in patients with alcoholism, malnutrition, or HIV. Its chronic waxing-and-waning course makes it difficult to diagnose. A 53-year-old male presented with pain and redness in his right eye for the past 3 weeks. The cornea had paracentral ulcer with stromal infiltrates and multiple satellite lesions giving wreath-like appearance suggestive of Nocardia. After corneal scraping, fortified amikacin, moxifloxacin, and cycloplegics were started. Gram stain revealed filamentous, branching Gram-positive bacteria and acid-fast on Ziehl-Neelsen stain confirming our clinical diagnosis. Ulcer completely resolved over 6 weeks. Thus, a high index of clinical suspicion which was further backed by microbiological confirmation aided in expedient management ensuring a successful outcome.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Oman Journal of Ophthalmology
Oman Journal of Ophthalmology Medicine-Ophthalmology
CiteScore
0.50
自引率
0.00%
发文量
68
审稿时长
50 weeks
期刊介绍: To provide a platform for scientific expression of the Oman Ophthalmic Society and the international Ophthalmic community and to provide opportunities for free exchange of ideas and information. To serve as a valuable resource for ophthalmologists, eye-care providers including optometrists, orthoptists, other health care professionals and research workers in all aspects of the field of visual science.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信