2019年至2023年芬太尼在儿科尸检人群中的流行率。

IF 1.5 4区 医学 Q2 MEDICINE, LEGAL
Brianna L. Peterson PhD, Kari M. Midthun PhD
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引用次数: 0

摘要

在过去的十年中,非法制造的芬太尼一直是导致吸毒过量死亡的主要原因,不分年龄。儿科人群尤其容易接触芬太尼,但涉及这一人群的病例报告却很有限。我们对 2019 年至 2023 年的尸检病例进行了回顾性分析,以确定芬太尼在 0 至 12 岁死者中的流行率。在这段时间内,芬太尼阳性率从 2.6% 上升至 6.2%(n = 632)。最常报告的年龄组是 0-4 岁,幼儿在 1 岁左右达到高峰。血液中的芬太尼浓度(n = 573)从 0.19 毫微克/毫升到 360 毫微克/毫升不等(平均值为 18 毫微克/毫升,中位值为 6.9 毫微克/毫升)。在 428 例病例中存在使用多种药物的情况;咪达唑仑(n = 96)和甲基苯丙胺(n = 66)是血液中发现的与芬太尼同时存在的最常见药物,其次是非法制造的芬太尼的标记物,如恶嗪(n = 23)、对氟芬太尼(n = 18)和乙酰芬太尼(n = 17)。本报告对比了三组病例中小儿芬太尼死后毒理结果的差异:可能的医疗干预(n = 113)、与妊娠/分娩相关(n = 136)和无意/有意暴露(n = 196)。总之,本研究对小儿死后芬太尼在各种生物基质中的浓度进行了回顾性分析,并强调了在小儿死后病例工作中进行全面毒理学检测的必要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Prevalence of fentanyl in the pediatric postmortem population from 2019 to 2023

For the past decade, illicitly manufactured fentanyl has been a primary contributor in drug overdose deaths regardless of age. The pediatric population is particularly vulnerable to fentanyl exposure, yet there are limited case reports involving this population. Postmortem cases from 2019 to 2023 were retrospectively analyzed to determine the prevalence of fentanyl in decedents between 0 and 12 years of age. Over this time frame, the fentanyl positivity rate increased from 2.6 to 6.2% (n = 632). The most commonly reported age group was 0–4 years, with a peak around 1 year of age for toddlers. Fentanyl concentrations in blood (n = 573) ranged from 0.19 to 360 ng/mL (mean 18 ng/mL, median 6.9 ng/mL). Polydrug use was present in 428 cases; midazolam (n = 96) and methamphetamine (n = 66) were the most common drugs found concurrently in blood with fentanyl, followed by markers of illicitly manufactured fentanyl, such as xylazine (n = 23), para-fluorofentanyl (n = 18), and acetyl fentanyl (n = 17). This report contrasts the differences in postmortem pediatric fentanyl toxicology results for three groups of case histories: likely medical intervention (n = 113), pregnancy/birth related (n = 136), and inadvertent/intentional exposure (n = 196). Overall, this study provides a retrospective review of postmortem pediatric fentanyl concentrations in a variety of biological matrices and highlights the need for comprehensive toxicology testing in postmortem pediatric casework.

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来源期刊
Journal of forensic sciences
Journal of forensic sciences 医学-医学:法
CiteScore
4.00
自引率
12.50%
发文量
215
审稿时长
2 months
期刊介绍: The Journal of Forensic Sciences (JFS) is the official publication of the American Academy of Forensic Sciences (AAFS). It is devoted to the publication of original investigations, observations, scholarly inquiries and reviews in various branches of the forensic sciences. These include anthropology, criminalistics, digital and multimedia sciences, engineering and applied sciences, pathology/biology, psychiatry and behavioral science, jurisprudence, odontology, questioned documents, and toxicology. Similar submissions dealing with forensic aspects of other sciences and the social sciences are also accepted, as are submissions dealing with scientifically sound emerging science disciplines. The content and/or views expressed in the JFS are not necessarily those of the AAFS, the JFS Editorial Board, the organizations with which authors are affiliated, or the publisher of JFS. All manuscript submissions are double-blind peer-reviewed.
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