大鼠肾脏单剂量和多剂量注射钆沉积和 T1 信号强度变化的时间评估:一项实验研究

IF 0.9 Q3 MEDICINE, GENERAL & INTERNAL
Fatih Alper, Adem Karaman, Ahmet Yalçın, Büşra Diyarbakır Şirinoğlu, Büşra Dinçer, Alptuğ Atila, Serhat Kaya, Taha Tavacı
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引用次数: 0

摘要

背景: 钆在生物组织中的沉积最早见于肾衰竭患者。我们的目的是研究大鼠肾脏在接触单剂量和多剂量钆后的钆沉积情况,并评估1个月和3个月的沉积情况。我们还旨在确定沉积量与 T1 加权图像强度之间的相关性: 样本中有 70 只大鼠(每组 5 只),其中 9 组接受了单剂量(0.3、0.6 和 1.2 mmol/kg)钆,每种剂量的 1 组在第一天、一周和一个月结束时牺牲。四组每周接受一次剂量(0.3 和 0.6 毫摩尔/千克),分别在 6 周和 12 周后牺牲。牺牲前利用注射后图像测量 T1 强度,并利用电感耦合等离子体质谱测定沉积物: 结果:注射次数与钆沉积增加有关(P 结论:注射次数越多,钆沉积越多: 在注射后阶段,沉积与剂量有关,而在后期阶段,沉积与剂量或注射次数无关,直到第 12 周。T1信号强度测量对评估大鼠肾脏沉积情况并不可靠。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Temporal Assessment of Gadolinium Deposition and T1 Signal Intensity Changes in Rat Kidney with Single and Multiple Doses of Injection: An Experimental Study.

Background:  Gadolinium deposition in biological tissues was first reported in patients with renal failure. We aimed to investigate gadolinium deposition in the rat kidney after exposure to single and multiple doses of gadolinium and evaluate deposition for 1- and 3-month periods. We also aimed to determine any correlation between the amount of deposition and T1-weighted image intensity.

Methods:  Seventy rats (5 animals per group) were included in the sample, and 9 groups received a single dose (0.3, 0.6, and 1.2 mmol/kg) of gadolinium, and 1 group for each dose was sacrificed at the end of the first day, week, and month. Four groups received weekly doses (0.3 and 0.6 mmol/kg) and were sacrificed at the end of 6 and 12 weeks. Measurement of T1 intensities was carried out with postinjection images before sacrifice, and deposition was determined using inductively coupled plasma mass spectrometry.

Results:  The number of injections was associated with increased gadolinium deposition (P <.001) in the kidney. After the weekly injections, the deposited gadolinium levels did not significantly difer between the low and medium doses at the end of the sixth week (P=.067). There was no agreement between the observers regarding the measurement of T1 signal intensity in both single-dose and multidose experiments (P=.263 and P=.307, respectively).

Conclusion:  Deposition was dose dependent in the postinjection stage in contrast to the late stage in which deposition was not associated with dose or number of injections until the 12th week. T1 signal intensity measurement is unreliable for assessing deposition in the rat kidney.

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来源期刊
Eurasian Journal of Medicine
Eurasian Journal of Medicine Medicine-Medicine (all)
CiteScore
1.90
自引率
6.70%
发文量
59
审稿时长
16 weeks
期刊介绍: Eurasian Journal of Medicine (Eurasian J Med) is an international, scientific, open access periodical published by independent, unbiased, and triple-blinded peer-review principles. The journal is the official publication of Atatürk University School of Medicine and published triannually in February, June, and October. The publication language of the journal is English. The aim of the Eurasian Journal of Medicine is to publish original research papers of the highest scientific and clinical value in all medical fields. The Eurasian J Med also includes reviews, editorial short notes and letters to the editor that either as a comment related to recently published articles in our journal or as a case report. The target audience of the journal includes researchers, physicians and healthcare professionals who are interested or working in in all medical disciplines.
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