Bo Zhou, Xia Qu, Minjun Li, Xi Wang, Qi Xu, Jianhong Wang, Xiaoli Liu, Lili Zhang, Ting Zhang, Jialu Gu, Lijun Zhou, Nan Peng, Wenquan Niu, Lin Wang
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The data were analyzed by the R coding platform version 4.3.0.</p><p><strong>Results: </strong>Under the Chinese criteria, 29%, 15%, and 4% of boys with overweight; 33%, 33%, and 3% of boys with obesity; 39%, 25%, and 2% of girls with overweight; and 37%, 42% and 1% of girls with obesity had advanced, significantly advanced and delayed BA, respectively. After adjustment, overweight (odds ratio, 95% confidence interval, P under the Chinese criteria: 2.52, 2.30-2.75, <0.001 and 4.54, 4.06-5.09, <0.001) and obesity (4.31, 3.85-4.82, <0.001 and 14.01, 12.39-15.85, <0.001) were risk factors for both advanced BA and significantly advanced BA.</p><p><strong>Conclusions: </strong>Different nutritional statuses lead to differences in children's BA development. Children with overweight and obesity have higher rates of advanced BA under two growth criteria, and girls have more advances in BA than boys do. Overweight and obesity are risk factors for advanced BA.</p>","PeriodicalId":49211,"journal":{"name":"Endocrine","volume":" ","pages":"304-313"},"PeriodicalIF":3.0000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11739253/pdf/","citationCount":"0","resultStr":"{\"title\":\"Correlation of bone age development with overweight and obesity in 23,305 children from Beijing.\",\"authors\":\"Bo Zhou, Xia Qu, Minjun Li, Xi Wang, Qi Xu, Jianhong Wang, Xiaoli Liu, Lili Zhang, Ting Zhang, Jialu Gu, Lijun Zhou, Nan Peng, Wenquan Niu, Lin Wang\",\"doi\":\"10.1007/s12020-024-03988-w\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>The aim of this study was to observe the influence of differential nutritional status on bone age (BA) change according to body mass index (BMI) and analyze the risk of advanced bone age in children with overweight and obesity.</p><p><strong>Methods: </strong>In total 23,305 children from Beijing were included in this cross-sectional study. 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引用次数: 0
摘要
目的：本研究旨在根据体重指数（BMI）观察不同营养状况对骨龄（BA）变化的影响，并分析超重和肥胖儿童骨龄提前的风险：这项横断面研究共纳入了 23 305 名北京儿童。根据中国和世界卫生组织的生长标准界定儿童超重和肥胖。数据采用 R 编码平台 4.3.0 版进行分析：根据中国标准，超重男孩中分别有 29%、15% 和 4%；肥胖男孩中分别有 33%、33% 和 3%；超重女孩中分别有 39%、25% 和 2%；肥胖女孩中分别有 37%、42% 和 1%的发育提前、明显提前和发育延迟。经调整后，超重（中国标准下的几率比率、95% 置信区间、P2.52，2.30-2.75，结论：不同的营养状况导致儿童 BA 发育的差异。根据两种生长标准，超重和肥胖儿童的 BA 超前率更高，女孩的 BA 超前率高于男孩。超重和肥胖是发育迟缓的风险因素。
Correlation of bone age development with overweight and obesity in 23,305 children from Beijing.
Purpose: The aim of this study was to observe the influence of differential nutritional status on bone age (BA) change according to body mass index (BMI) and analyze the risk of advanced bone age in children with overweight and obesity.
Methods: In total 23,305 children from Beijing were included in this cross-sectional study. Childhood overweight and obesity were defined according to the China and World Health Organization growth criteria. The data were analyzed by the R coding platform version 4.3.0.
Results: Under the Chinese criteria, 29%, 15%, and 4% of boys with overweight; 33%, 33%, and 3% of boys with obesity; 39%, 25%, and 2% of girls with overweight; and 37%, 42% and 1% of girls with obesity had advanced, significantly advanced and delayed BA, respectively. After adjustment, overweight (odds ratio, 95% confidence interval, P under the Chinese criteria: 2.52, 2.30-2.75, <0.001 and 4.54, 4.06-5.09, <0.001) and obesity (4.31, 3.85-4.82, <0.001 and 14.01, 12.39-15.85, <0.001) were risk factors for both advanced BA and significantly advanced BA.
Conclusions: Different nutritional statuses lead to differences in children's BA development. Children with overweight and obesity have higher rates of advanced BA under two growth criteria, and girls have more advances in BA than boys do. Overweight and obesity are risk factors for advanced BA.
期刊介绍：
Well-established as a major journal in today’s rapidly advancing experimental and clinical research areas, Endocrine publishes original articles devoted to basic (including molecular, cellular and physiological studies), translational and clinical research in all the different fields of endocrinology and metabolism. Articles will be accepted based on peer-reviews, priority, and editorial decision. Invited reviews, mini-reviews and viewpoints on relevant pathophysiological and clinical topics, as well as Editorials on articles appearing in the Journal, are published. Unsolicited Editorials will be evaluated by the editorial team. Outcomes of scientific meetings, as well as guidelines and position statements, may be submitted. The Journal also considers special feature articles in the field of endocrine genetics and epigenetics, as well as articles devoted to novel methods and techniques in endocrinology.
Endocrine covers controversial, clinical endocrine issues. Meta-analyses on endocrine and metabolic topics are also accepted. Descriptions of single clinical cases and/or small patients studies are not published unless of exceptional interest. However, reports of novel imaging studies and endocrine side effects in single patients may be considered. Research letters and letters to the editor related or unrelated to recently published articles can be submitted.
Endocrine covers leading topics in endocrinology such as neuroendocrinology, pituitary and hypothalamic peptides, thyroid physiological and clinical aspects, bone and mineral metabolism and osteoporosis, obesity, lipid and energy metabolism and food intake control, insulin, Type 1 and Type 2 diabetes, hormones of male and female reproduction, adrenal diseases pediatric and geriatric endocrinology, endocrine hypertension and endocrine oncology.
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