从肾脏病专家的角度看肾脏单克隆抗体病。

IF 2.3 Q2 HEMATOLOGY
Kootae Park, Soon Hyo Kwon
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引用次数: 0

摘要

肾脏疾病是多发性骨髓瘤和其他与单克隆丙种球蛋白病相关的恶性肿瘤的常见并发症。此外,蛋白尿异常相关的肾脏疾病也可能独立于明显的多发性骨髓瘤或血液恶性肿瘤而发生。肾脏单克隆抗体病(MGRS)是一种由良性或恶性前 B 细胞或浆细胞克隆产生的单克隆免疫球蛋白导致肾脏损伤的疾病。与 MGRS 相关的肾脏疾病有多种表现形式,包括免疫球蛋白相关性淀粉样变性、单克隆免疫球蛋白沉积病(轻链、重链以及轻重链联合沉积病)、伴有单克隆免疫球蛋白沉积的增生性肾小球肾炎、伴有单克隆丙种球蛋白病的 C3 肾小球病以及轻链近端肾小管病。虽然 MGRS 是一种非恶性或恶性前血液病,但它对肾脏有重大影响,往往会导致进行性肾损害,最终导致终末期肾病。这篇综述讨论了 MGRS 的流行病学、发病机制和治疗方法,重点从肾病学家的角度进行分析。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Monoclonal gammopathy of renal significance from the perspective of nephrologists.

Kidney disease is a frequent complication of multiple myeloma and other malignancies associated with monoclonal gammopathies. Additionally, dysproteinemia-related kidney disease can occur independently of overt multiple myeloma or hematologic malignancies. Monoclonal gammopathy of renal significance (MGRS) is a spectrum of disorders in which a monoclonal immunoglobulin produced by a benign or premalignant B-cell or plasma cell clone causes kidney damage. MGRS-associated renal disease manifests in various forms, including immunoglobulin-associated amyloidosis, monoclonal immunoglobulin deposition diseases (light chain, heavy chain, and combined light and heavy chain deposition diseases), proliferative glomerulonephritis with monoclonal immunoglobulin deposits, C3 glomerulopathy with monoclonal gammopathy, and light chain proximal tubulopathy. Although MGRS is a nonmalignant or premalignant hematologic condition, it has significant renal implications that often lead to progressive kidney damage and, eventually, end-stage kidney disease. This review discusses the epidemiology, pathogenesis, and management of MGRS and focuses on the perspective of nephrologists.

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来源期刊
Blood Research
Blood Research HEMATOLOGY-
CiteScore
3.70
自引率
0.00%
发文量
64
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