弓形虫免疫球蛋白血清阳性率及其与系统性红斑狼疮的关系:系统回顾与荟萃分析。

IF 1.9 4区 医学 Q3 RHEUMATOLOGY
Lupus Pub Date : 2024-10-01 Epub Date: 2024-08-11 DOI:10.1177/09612033241273048
Shovit Ranjan, Aditya K Panda
{"title":"弓形虫免疫球蛋白血清阳性率及其与系统性红斑狼疮的关系:系统回顾与荟萃分析。","authors":"Shovit Ranjan, Aditya K Panda","doi":"10.1177/09612033241273048","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>The exact cause of systemic lupus erythematosus (SLE) is still unknown. However, hormonal, genetic, and environmental factors may play significant roles in its development. Infection has been recognized as a crucial trigger for SLE development. Several studies have reported a higher prevalence of <i>Toxoplasma gondii</i> infections in patients with SLE than in healthy individuals. However, these results were inconsistent. Therefore, this study aimed to conduct a systematic review and meta-analysis of published studies to provide a definitive conclusion regarding the relationship between <i>T. gondii</i> infection and SLE.</p><p><strong>Materials and methods: </strong>We conducted a comprehensive search across diverse databases using an array of search tools to uncover pertinent literature. Following the stringent application of the inclusion and exclusion criteria, we carefully selected the appropriate reports for our meta-analysis. Using Comprehensive Meta-Analysis software v4, we analyzed the data and determined the prevalence of antibodies against <i>T. gondii</i> in patients affected with SLE. To investigate the correlation between <i>T. gondii</i> seropositivity and SLE, we computed the risk ratios (RRs) and 95% confidence intervals (CI).</p><p><strong>Results: </strong>Eleven studies were considered eligible for inclusion in the present study. The prevalence of anti-IgG and IgM antibodies against <i>T. gondii</i> was 33.9% and 7.7%, respectively. A significant association between <i>T. gondii</i> IgG seropositivity and SLE was observed when compared to the controls (risk ratio = 2.14, 95% CI = 1.42 to 3.22, <i>p</i> = .000). However, IgM seropositivity against <i>T. gondii</i> was comparable between patients with SLE and healthy controls.</p><p><strong>Conclusions: </strong>In summary, this study suggests that <i>T. gondii</i> IgG is more prevalent in patients with SLE than in healthy individuals in areas where <i>T. gondii</i> infections are more frequent. However, an exact cause-and-effect relationship still needs to be established. Therefore, additional research is necessary to validate these findings and to investigate the underlying mechanisms.</p>","PeriodicalId":18044,"journal":{"name":"Lupus","volume":null,"pages":null},"PeriodicalIF":1.9000,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Seroprevalence of <i>Toxoplasma gondii</i> immunoglobulins and its association with systemic lupus erythematosus: A systematic review and meta-analysis.\",\"authors\":\"Shovit Ranjan, Aditya K Panda\",\"doi\":\"10.1177/09612033241273048\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>The exact cause of systemic lupus erythematosus (SLE) is still unknown. However, hormonal, genetic, and environmental factors may play significant roles in its development. Infection has been recognized as a crucial trigger for SLE development. Several studies have reported a higher prevalence of <i>Toxoplasma gondii</i> infections in patients with SLE than in healthy individuals. However, these results were inconsistent. Therefore, this study aimed to conduct a systematic review and meta-analysis of published studies to provide a definitive conclusion regarding the relationship between <i>T. gondii</i> infection and SLE.</p><p><strong>Materials and methods: </strong>We conducted a comprehensive search across diverse databases using an array of search tools to uncover pertinent literature. Following the stringent application of the inclusion and exclusion criteria, we carefully selected the appropriate reports for our meta-analysis. Using Comprehensive Meta-Analysis software v4, we analyzed the data and determined the prevalence of antibodies against <i>T. gondii</i> in patients affected with SLE. To investigate the correlation between <i>T. gondii</i> seropositivity and SLE, we computed the risk ratios (RRs) and 95% confidence intervals (CI).</p><p><strong>Results: </strong>Eleven studies were considered eligible for inclusion in the present study. The prevalence of anti-IgG and IgM antibodies against <i>T. gondii</i> was 33.9% and 7.7%, respectively. A significant association between <i>T. gondii</i> IgG seropositivity and SLE was observed when compared to the controls (risk ratio = 2.14, 95% CI = 1.42 to 3.22, <i>p</i> = .000). However, IgM seropositivity against <i>T. gondii</i> was comparable between patients with SLE and healthy controls.</p><p><strong>Conclusions: </strong>In summary, this study suggests that <i>T. gondii</i> IgG is more prevalent in patients with SLE than in healthy individuals in areas where <i>T. gondii</i> infections are more frequent. However, an exact cause-and-effect relationship still needs to be established. Therefore, additional research is necessary to validate these findings and to investigate the underlying mechanisms.</p>\",\"PeriodicalId\":18044,\"journal\":{\"name\":\"Lupus\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2024-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Lupus\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1177/09612033241273048\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/8/11 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"RHEUMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Lupus","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/09612033241273048","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/8/11 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"RHEUMATOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

背景:系统性红斑狼疮(SLE)的确切病因尚不清楚。然而,激素、遗传和环境因素可能在其发病过程中起着重要作用。感染已被认为是系统性红斑狼疮发病的一个重要诱因。一些研究报告称,系统性红斑狼疮患者的弓形虫感染率高于健康人。然而,这些结果并不一致。因此,本研究旨在对已发表的研究进行系统回顾和荟萃分析,以便就弓形虫感染与系统性红斑狼疮之间的关系得出明确结论:我们使用一系列搜索工具对各种数据库进行了全面搜索,以发现相关文献。在严格执行纳入和排除标准后,我们精心挑选了合适的报告进行荟萃分析。我们使用综合荟萃分析软件 v4 对数据进行了分析,并确定了系统性红斑狼疮患者体内淋球菌抗体的流行率。为了研究淋球菌血清阳性与系统性红斑狼疮之间的相关性,我们计算了风险比(RR)和95%置信区间(CI):有 11 项研究符合纳入本研究的条件。针对淋球菌的抗 IgG 和 IgM 抗体的流行率分别为 33.9% 和 7.7%。与对照组相比,T. gondii IgG 血清阳性与系统性红斑狼疮之间存在明显的关联(风险比 = 2.14,95% CI = 1.42 至 3.22,p = .000)。然而,系统性红斑狼疮患者与健康对照组的淋球菌IgM血清阳性率相当:总之,这项研究表明,在淋病感染较为频繁的地区,系统性红斑狼疮患者的淋病双球菌 IgG 阳性率高于健康人。然而,确切的因果关系仍有待确定。因此,有必要进行更多的研究来验证这些发现并探究其背后的机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Seroprevalence of Toxoplasma gondii immunoglobulins and its association with systemic lupus erythematosus: A systematic review and meta-analysis.

Background: The exact cause of systemic lupus erythematosus (SLE) is still unknown. However, hormonal, genetic, and environmental factors may play significant roles in its development. Infection has been recognized as a crucial trigger for SLE development. Several studies have reported a higher prevalence of Toxoplasma gondii infections in patients with SLE than in healthy individuals. However, these results were inconsistent. Therefore, this study aimed to conduct a systematic review and meta-analysis of published studies to provide a definitive conclusion regarding the relationship between T. gondii infection and SLE.

Materials and methods: We conducted a comprehensive search across diverse databases using an array of search tools to uncover pertinent literature. Following the stringent application of the inclusion and exclusion criteria, we carefully selected the appropriate reports for our meta-analysis. Using Comprehensive Meta-Analysis software v4, we analyzed the data and determined the prevalence of antibodies against T. gondii in patients affected with SLE. To investigate the correlation between T. gondii seropositivity and SLE, we computed the risk ratios (RRs) and 95% confidence intervals (CI).

Results: Eleven studies were considered eligible for inclusion in the present study. The prevalence of anti-IgG and IgM antibodies against T. gondii was 33.9% and 7.7%, respectively. A significant association between T. gondii IgG seropositivity and SLE was observed when compared to the controls (risk ratio = 2.14, 95% CI = 1.42 to 3.22, p = .000). However, IgM seropositivity against T. gondii was comparable between patients with SLE and healthy controls.

Conclusions: In summary, this study suggests that T. gondii IgG is more prevalent in patients with SLE than in healthy individuals in areas where T. gondii infections are more frequent. However, an exact cause-and-effect relationship still needs to be established. Therefore, additional research is necessary to validate these findings and to investigate the underlying mechanisms.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Lupus
Lupus 医学-风湿病学
CiteScore
4.20
自引率
11.50%
发文量
225
审稿时长
1 months
期刊介绍: The only fully peer reviewed international journal devoted exclusively to lupus (and related disease) research. Lupus includes the most promising new clinical and laboratory-based studies from leading specialists in all lupus-related disciplines. Invaluable reading, with extended coverage, lupus-related disciplines include: Rheumatology, Dermatology, Immunology, Obstetrics, Psychiatry and Cardiovascular Research…
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信