马齿苋酚酰胺甲基（3,4,5-三甲氧基苯甲酰基）缬氨酰丙酸酯通过 NLRP3 和 NF-κB 通路减轻邻苯二甲酸二乙基己酯诱导的人脐静脉内皮细胞炎症。

IF 1.7 3区农林科学 Q4 CHEMISTRY, MEDICINAL

Journal of medicinal food Pub Date : 2024-10-01 Epub Date: 2024-08-12 DOI:10.1089/jmf.2024.k.0016

Fanli Bu, Man Zheng, Na Li, Xiafeng Yan, Hongwei Xin, Yeting Li, Fenglei Zhang

{"title":"马齿苋酚酰胺甲基（3,4,5-三甲氧基苯甲酰基）缬氨酰丙酸酯通过 NLRP3 和 NF-κB 通路减轻邻苯二甲酸二乙基己酯诱导的人脐静脉内皮细胞炎症。","authors":"Fanli Bu, Man Zheng, Na Li, Xiafeng Yan, Hongwei Xin, Yeting Li, Fenglei Zhang","doi":"10.1089/jmf.2024.k.0016","DOIUrl":null,"url":null,"abstract":"Twelve polyphenol derivatives were obtained in a protective activity-guided isolation from the Portulaca oleracea L. extract on a cell model of human umbilical vein endothelial cells (HUVECs) under diethylhexyl phthalate (DEHP) exposure. Among them, methyl (3,4,5-trimethoxybenzoyl) valylprolinate (PP-10) performed the most protective activity and inhibited DEHP exposure-induced HUVECs' apoptosis. PP-10 also inhibited the DEHP-induced inflammatory cytokines (TNF-α, IL-6, IL-1β, and IL-8) and adhesion molecule (ICAM-1 andVCAM-1) overexpression. Furthermore, DEHP-induced NLRP3 inflammasomes' and NF-κB signaling pathway activation was significantly inhibited after the PP-10 treatments. Of note, the current results suggest the potential application of Portulaca oleracea L. and PP-10 in the prevention of DEHP-induced inflammatory damages in HUVECs.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":null,"pages":null},"PeriodicalIF":1.7000,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Portulaca Oleracea L. Phenolic Amide Methyl (3,4,5-Trimethoxybenzoyl) Valylprolinate Attenuates Diethylhexyl Phthalate-Induced Human Umbilical Vein Endothelial Cells' Inflammation Through NLRP3 and NF-κB Pathways.\",\"authors\":\"Fanli Bu, Man Zheng, Na Li, Xiafeng Yan, Hongwei Xin, Yeting Li, Fenglei Zhang\",\"doi\":\"10.1089/jmf.2024.k.0016\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Twelve polyphenol derivatives were obtained in a protective activity-guided isolation from the Portulaca oleracea L. extract on a cell model of human umbilical vein endothelial cells (HUVECs) under diethylhexyl phthalate (DEHP) exposure. Among them, methyl (3,4,5-trimethoxybenzoyl) valylprolinate (PP-10) performed the most protective activity and inhibited DEHP exposure-induced HUVECs' apoptosis. PP-10 also inhibited the DEHP-induced inflammatory cytokines (TNF-α, IL-6, IL-1β, and IL-8) and adhesion molecule (ICAM-1 andVCAM-1) overexpression. Furthermore, DEHP-induced NLRP3 inflammasomes' and NF-κB signaling pathway activation was significantly inhibited after the PP-10 treatments. Of note, the current results suggest the potential application of Portulaca oleracea L. and PP-10 in the prevention of DEHP-induced inflammatory damages in HUVECs.\",\"PeriodicalId\":16440,\"journal\":{\"name\":\"Journal of medicinal food\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2024-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of medicinal food\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://doi.org/10.1089/jmf.2024.k.0016\",\"RegionNum\":3,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/8/12 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of medicinal food","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1089/jmf.2024.k.0016","RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/8/12 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}

引用次数: 0

摘要

在邻苯二甲酸二乙基己酯（DEHP）暴露条件下，对人脐静脉内皮细胞（HUVECs）的细胞模型进行了保护活性指导分离，从马齿苋提取物中获得了 12 种多酚衍生物。其中，(3,4,5-三甲氧基苯甲酰基)缬氨酰丙酸甲酯（PP-10）具有最强的保护活性，可抑制 DEHP 暴露诱导的 HUVECs 细胞凋亡。PP-10 还能抑制 DEHP 诱导的炎性细胞因子（TNF-α、IL-6、IL-1β 和 IL-8）和粘附分子（ICAM-1 和VCAM-1）的过度表达。此外，经 PP-10 处理后，DEHP 诱导的 NLRP3 炎性体和 NF-κB 信号通路的激活也受到了显著抑制。值得注意的是，目前的研究结果表明，马齿苋和 PP-10 在预防 DEHP 诱导的 HUVECs 炎症损伤方面具有潜在的应用价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Portulaca Oleracea L. Phenolic Amide Methyl (3,4,5-Trimethoxybenzoyl) Valylprolinate Attenuates Diethylhexyl Phthalate-Induced Human Umbilical Vein Endothelial Cells' Inflammation Through NLRP3 and NF-κB Pathways.

Twelve polyphenol derivatives were obtained in a protective activity-guided isolation from the Portulaca oleracea L. extract on a cell model of human umbilical vein endothelial cells (HUVECs) under diethylhexyl phthalate (DEHP) exposure. Among them, methyl (3,4,5-trimethoxybenzoyl) valylprolinate (PP-10) performed the most protective activity and inhibited DEHP exposure-induced HUVECs' apoptosis. PP-10 also inhibited the DEHP-induced inflammatory cytokines (TNF-α, IL-6, IL-1β, and IL-8) and adhesion molecule (ICAM-1 andVCAM-1) overexpression. Furthermore, DEHP-induced NLRP3 inflammasomes' and NF-κB signaling pathway activation was significantly inhibited after the PP-10 treatments. Of note, the current results suggest the potential application of Portulaca oleracea L. and PP-10 in the prevention of DEHP-induced inflammatory damages in HUVECs.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Journal of medicinal food 医学-食品科技

CiteScore

4.50

自引率

0.00%

发文量

154

审稿时长

4.5 months

期刊介绍： Journal of Medicinal Food is the only peer-reviewed journal focusing exclusively on the medicinal value and biomedical effects of food materials. International in scope, the Journal advances the knowledge of the development of new food products and dietary supplements targeted at promoting health and the prevention and treatment of disease.