Endang S Rahayu, Wahyu K Yoga, Husnita Komalasari, Mariyatun Mariyatun, Wednes A Yuda, Nancy E P Manurung, Pratama N Hasan, Suharman Suharman, Fathyah H Pamungkaningtyas, Dina A Nurfiana, Putrika C Pramesi, Mifta Gatya, Phatthanaphong Therdtatha, Jiro Nakayama, Mohammad Juffrie, Titiek F Djaafar, Tri Marwati, Tyas Utami
{"title":"含有植物乳杆菌 Dad-13 的益生菌巧克力可改变龙目岛营养不良儿童的肠道微生物群组成：一项随机双盲试验。","authors":"Endang S Rahayu, Wahyu K Yoga, Husnita Komalasari, Mariyatun Mariyatun, Wednes A Yuda, Nancy E P Manurung, Pratama N Hasan, Suharman Suharman, Fathyah H Pamungkaningtyas, Dina A Nurfiana, Putrika C Pramesi, Mifta Gatya, Phatthanaphong Therdtatha, Jiro Nakayama, Mohammad Juffrie, Titiek F Djaafar, Tri Marwati, Tyas Utami","doi":"10.1155/2024/9493797","DOIUrl":null,"url":null,"abstract":"<p><p>The present study investigated the ingestion effect of chocolate probiotic containing <i>Lactobacillus plantarum</i> Dad-13 in undernourished children. A 100-day observation was conducted on undernourished children in Lombok, who were divided into probiotic (<i>n</i> = 28) and placebo (<i>n</i> = 28) groups. Fecal sampling was performed on the 10<sup>th</sup> and 100<sup>th</sup> days and further analyzed for gut microbiota composition, short-chain fatty acid (SCFA), and fecal pH. A significant difference was found in the diversity index, fecal pH, and several microbiotas at the phylum and genus levels. At the phylum level, <i>Bacteroidetes</i> was significantly higher in the probiotic group, and a higher relative abundance (RA) of <i>Firmicutes</i> was found in the placebo group. At the genus level, significant differences were observed in some bacteria, such as <i>Bifidobacterium</i> and <i>Prevotella</i>. Therefore, it can be concluded that the probiotic intervention in this study resulted in changes of gut microbiota diversity and fecal pH. <b>Trial Registration:</b> Thai Clinical Trials Registry identifier: TCTR20220425001.</p>","PeriodicalId":14125,"journal":{"name":"International Journal of Food Science","volume":null,"pages":null},"PeriodicalIF":2.7000,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11316911/pdf/","citationCount":"0","resultStr":"{\"title\":\"Probiotic Chocolate Containing <i>Lactobacillus plantarum</i> Dad-13 Alters the Gut Microbiota Composition of Undernourished Children in Lombok: A Randomized Double-Blind Trial.\",\"authors\":\"Endang S Rahayu, Wahyu K Yoga, Husnita Komalasari, Mariyatun Mariyatun, Wednes A Yuda, Nancy E P Manurung, Pratama N Hasan, Suharman Suharman, Fathyah H Pamungkaningtyas, Dina A Nurfiana, Putrika C Pramesi, Mifta Gatya, Phatthanaphong Therdtatha, Jiro Nakayama, Mohammad Juffrie, Titiek F Djaafar, Tri Marwati, Tyas Utami\",\"doi\":\"10.1155/2024/9493797\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The present study investigated the ingestion effect of chocolate probiotic containing <i>Lactobacillus plantarum</i> Dad-13 in undernourished children. A 100-day observation was conducted on undernourished children in Lombok, who were divided into probiotic (<i>n</i> = 28) and placebo (<i>n</i> = 28) groups. Fecal sampling was performed on the 10<sup>th</sup> and 100<sup>th</sup> days and further analyzed for gut microbiota composition, short-chain fatty acid (SCFA), and fecal pH. A significant difference was found in the diversity index, fecal pH, and several microbiotas at the phylum and genus levels. At the phylum level, <i>Bacteroidetes</i> was significantly higher in the probiotic group, and a higher relative abundance (RA) of <i>Firmicutes</i> was found in the placebo group. At the genus level, significant differences were observed in some bacteria, such as <i>Bifidobacterium</i> and <i>Prevotella</i>. Therefore, it can be concluded that the probiotic intervention in this study resulted in changes of gut microbiota diversity and fecal pH. <b>Trial Registration:</b> Thai Clinical Trials Registry identifier: TCTR20220425001.</p>\",\"PeriodicalId\":14125,\"journal\":{\"name\":\"International Journal of Food Science\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2024-08-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11316911/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Food Science\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1155/2024/9493797\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"FOOD SCIENCE & TECHNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Food Science","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1155/2024/9493797","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"FOOD SCIENCE & TECHNOLOGY","Score":null,"Total":0}
Probiotic Chocolate Containing Lactobacillus plantarum Dad-13 Alters the Gut Microbiota Composition of Undernourished Children in Lombok: A Randomized Double-Blind Trial.
The present study investigated the ingestion effect of chocolate probiotic containing Lactobacillus plantarum Dad-13 in undernourished children. A 100-day observation was conducted on undernourished children in Lombok, who were divided into probiotic (n = 28) and placebo (n = 28) groups. Fecal sampling was performed on the 10th and 100th days and further analyzed for gut microbiota composition, short-chain fatty acid (SCFA), and fecal pH. A significant difference was found in the diversity index, fecal pH, and several microbiotas at the phylum and genus levels. At the phylum level, Bacteroidetes was significantly higher in the probiotic group, and a higher relative abundance (RA) of Firmicutes was found in the placebo group. At the genus level, significant differences were observed in some bacteria, such as Bifidobacterium and Prevotella. Therefore, it can be concluded that the probiotic intervention in this study resulted in changes of gut microbiota diversity and fecal pH. Trial Registration: Thai Clinical Trials Registry identifier: TCTR20220425001.
期刊介绍：
International Journal of Food Science is a peer-reviewed, Open Access journal that publishes research and review articles in all areas of food science. As a multidisciplinary journal, articles discussing all aspects of food science will be considered, including, but not limited to: enhancing shelf life, food deterioration, food engineering, food handling, food processing, food quality, food safety, microbiology, and nutritional research. The journal aims to provide a valuable resource for food scientists, food producers, food retailers, nutritionists, the public health sector, and relevant governmental and non-governmental agencies.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
