粘膜相关不变 T 细胞：肺部的动力源

IF 3.3 4区医学 Q3 IMMUNOLOGY

Immunology letters Pub Date : 2024-08-10 DOI:10.1016/j.imlet.2024.106910

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引用次数: 0

摘要

肺部不断面临来自无害分子、空气中的病原体和可损害组织的有害物质的环境挑战。肺部的免疫系统包括大量的组织驻留淋巴细胞，它们有助于维持组织的平衡和早期启动免疫反应。在组织驻留淋巴细胞中，粘膜相关不变T细胞（MAIT）存在于人类和鼠类的肺中，新的证据支持它们在感染、慢性炎症性疾病和癌症期间对免疫反应的贡献。这篇综述探讨了 MAIT 细胞在气道中发挥功能的机制、它们对肺免疫的影响以及针对肺 MAIT 细胞进行治疗的潜力。

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Mucosal associated invariant T cells: Powerhouses of the lung

The lungs face constant environmental challenges from harmless molecules, airborne pathogens and harmful agents that can damage the tissue. The lungs’ immune system includes numerous tissue-resident lymphocytes that contribute to maintain tissue homeostasis and to the early initiation of immune responses. Amongst tissue-resident lymphocytes, Mucosal Associated Invariant T (MAIT) cells are present in human and murine lungs and emerging evidence supports their contribution to immune responses during infections, chronic inflammatory disorders and cancer. This review explores the mechanisms underpinning MAIT cell functions in the airways, their impact on lung immunity and the potential for targeting pulmonary MAIT cells in a therapeutic context.

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来源期刊

Immunology letters 医学-免疫学

CiteScore

7.60

自引率

0.00%

发文量

审稿时长

44 days

期刊介绍： Immunology Letters provides a vehicle for the speedy publication of experimental papers, (mini)Reviews and Letters to the Editor addressing all aspects of molecular and cellular immunology. The essential criteria for publication will be clarity, experimental soundness and novelty. Results contradictory to current accepted thinking or ideas divergent from actual dogmas will be considered for publication provided that they are based on solid experimental findings. Preference will be given to papers of immediate importance to other investigators, either by their experimental data, new ideas or new methodology. Scientific correspondence to the Editor-in-Chief related to the published papers may also be accepted provided that they are short and scientifically relevant to the papers mentioned, in order to provide a continuing forum for discussion.