多米尼加共和国 2018 年至 2020 年登革热病毒流行期间幼儿全血细胞计数随时间变化的数值。

IF 2.6 3区 生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
BioMed Research International Pub Date : 2024-08-03 eCollection Date: 2024-01-01 DOI:10.1155/2024/3716786
Melissa E Day, Yonairy Collado Puello, Miguel E Mejía Sang, Elvira J Diaz Brockmans, María F Díaz Soto, Stephanie M Rivera Defilló, Karla M Taveras Cruz, Javier O Santiago Pérez, Rafael Meña, Cesár Mota, Margaret K Hostetter, Louis J Muglia, Javier Gonzalez Del Rey, Elizabeth P Schlaudecker, Lisa J Martin, Brittany N Simpson, Carlos E Prada
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引用次数: 0

摘要

背景:登革热(DF)是一种由蚊子传播的疾病,对经济和社会有重大影响。了解多米尼加共和国(DR)住院儿童患者的实验室趋势有助于在资源匮乏的环境中制定筛查程序。我们试图描述 2018 年至 2020 年期间多米尼加共和国 DF 儿童的实验室结果以及 DF 的严重程度。方法:从招募的 DF 儿童中前瞻性地获取临床信息。对发热第 1-10 天的全血细胞计数 (CBC) 实验室指标进行了评估。参与者被分为 DF 阴性和 DF 阳性,并按严重程度分组。我们评估了 DF 严重程度与人口统计学、临床特征和外周血研究的关联。利用线性混合模型,我们评估了血液学值/轨迹是否因 DF 状态/严重程度而异。结果:对 1101 例 DF 临床诊断患者中的 597 例进行了血清学评估,其中 574 例(471 例 DF 阳性)符合纳入标准。在 DF 患者中,发热天数越早,血小板计数和血红蛋白越高(P < = 0.0017)。80人患有严重的DF。重度 DF 风险与血小板减少、病中贫血和白细胞减少有关,因发烧天数而异(p < = 0.001)。结论在儿科住院DR队列中,我们发现严重DF晚期会出现明显的贫血,这与通常所见的血液浓缩不同。这些发现与随着时间推移出现的临床症状变化相结合,有助于指导在资源有限的环境中进行风险分级筛查。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Complete Blood Count Values Over Time in Young Children During the Dengue Virus Epidemic in the Dominican Republic From 2018 to 2020.

Background: Dengue fever (DF) is a mosquito-borne illness with substantial economic and societal impact. Understanding laboratory trends of hospitalized Dominican Republic (DR) pediatric patients could help develop screening procedures in low-resourced settings. We sought to describe laboratory findings over time in DR children with DF and DF severity from 2018 to 2020. Methods: Clinical information was obtained prospectively from recruited children with DF. Complete blood count (CBC) laboratory measures were assessed across Days 1-10 of fever. Participants were classified as DF-negative and DF-positive and grouped by severity. We assessed associations of DF severity with demographics, clinical characteristics, and peripheral blood studies. Using linear mixed-models, we assessed if hematologic values/trajectories differed by DF status/severity. Results: A total of 597 of 1101 with a DF clinical diagnosis were serologically evaluated, and 574 (471 DF-positive) met inclusion criteria. In DF, platelet count and hemoglobin were higher on earlier days of fever (p < = 0.0017). Eighty had severe DF. Severe DF risk was associated with thrombocytopenia, intraillness anemia, and leukocytosis, differing by fever day (p < = 0.001). Conclusions: In a pediatric hospitalized DR cohort, we found marked anemia in late stages of severe DF, unlike the typically seen hemoconcentration. These findings, paired with clinical symptom changes over time, may help guide risk-stratified screenings for resource-limited settings.

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来源期刊
BioMed Research International
BioMed Research International BIOTECHNOLOGY & APPLIED MICROBIOLOGY-MEDICINE, RESEARCH & EXPERIMENTAL
CiteScore
6.70
自引率
0.00%
发文量
1942
审稿时长
19 weeks
期刊介绍: BioMed Research International is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies covering a wide range of subjects in life sciences and medicine. The journal is divided into 55 subject areas.
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