中年人的瘦素生物利用率与脑萎缩和血管损伤指标

IF 13 1区 医学 Q1 CLINICAL NEUROLOGY
Sokratis Charisis, Meghan I. Short, Rebecca Bernal, Tiffany F. Kautz, Hector A. Treviño, Julia Mathews, Angel Gabriel Velarde Dediós, Jazmyn A. S. Muhammad, Alison M. Luckey, Asra Aslam, Jayandra J. Himali, Eric L. Shipp, Mohamad Habes, Alexa S. Beiser, Charles DeCarli, Nikolaos Scarmeas, Vasan S. Ramachandran, Sudha Seshadri, Pauline Maillard, Claudia L. Satizabal
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引用次数: 0

摘要

引言我们研究了瘦素标记物与健康中年人认知功能以及脑萎缩和血管损伤的磁共振成像(MRI)测量结果之间的关系:我们从弗雷明汉心脏研究(Framingham Heart Study)中选取了2262名认知能力健康、接受过神经心理学评估的参与者,其中2028人还接受了脑部核磁共振成像检查。使用酶联免疫吸附测定法测量了瘦素、可溶性瘦素受体(sOB-R)的浓度及其比率(游离瘦素指数 [FLI]),这表明瘦素的生物利用率。认知和核磁共振成像测量采用标准化方案进行:结果:较高的 sOB-R 与较低的分数各向异性(FA,β = -0.114 ± 0.02,p 讨论)相关:在健康的中年人中,较高的瘦素生物利用度与较好的白质(WM)完整性相关,支持瘦素在晚年痴呆风险中的潜在神经保护作用:亮点:较高的瘦素生物利用率与较好的白质微结构保护有关。中年时期较高的瘦素生物利用率可能会对痴呆症起到保护作用。内脏肥胖症患者的潜在益处可能更大。DTI测量可能是亚临床神经病理学的敏感替代标记。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Leptin bioavailability and markers of brain atrophy and vascular injury in the middle age

Leptin bioavailability and markers of brain atrophy and vascular injury in the middle age

INTRODUCTION

We investigated the associations of leptin markers with cognitive function and magnetic resonance imaging (MRI) measures of brain atrophy and vascular injury in healthy middle-aged adults.

METHODS

We included 2262 cognitively healthy participants from the Framingham Heart Study with neuropsychological evaluation; of these, 2028 also had available brain MRI. Concentrations of leptin, soluble leptin receptor (sOB-R), and their ratio (free leptin index [FLI]), indicating leptin bioavailability, were measured using enzyme-linked immunosorbent assays. Cognitive and MRI measures were derived using standardized protocols.

RESULTS

Higher sOB-R was associated with lower fractional anisotropy (FA, β = −0.114 ± 0.02, p < 0.001), and higher free water (FW, β = 0.091 ± 0.022, p < 0.001) and peak-width skeletonized mean diffusivity (PSMD, β = 0.078 ± 0.021, p < 0.001). Correspondingly, higher FLI was associated with higher FA (β = 0.115 ± 0.027, p < 0.001) and lower FW (β = -0.096 ± 0.029, p = 0.001) and PSMD (β = -0.085 ± 0.028, p = 0.002).

DISCUSSION

Higher leptin bioavailability was associated with better white matter (WM) integrity in healthy middle-aged adults, supporting the putative neuroprotective role of leptin in late-life dementia risk.

Highlights

  • Higher leptin bioavailability was related to better preservation of white matter microstructure.
  • Higher leptin bioavailability during midlife might confer protection against dementia.
  • Potential benefits might be even stronger for individuals with visceral obesity.
  • DTI measures might be sensitive surrogate markers of subclinical neuropathology.
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来源期刊
Alzheimer's & Dementia
Alzheimer's & Dementia 医学-临床神经学
CiteScore
14.50
自引率
5.00%
发文量
299
审稿时长
3 months
期刊介绍: Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.
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