胚胎非整倍体--辅助生殖技术的真正 "最后屏障"？

F&S science Pub Date : 2024-11-01 DOI:10.1016/j.xfss.2024.08.002

Alexander M. Quaas M.D., Ph.D. , Alan S. Penzias M.D. , Eli Y. Adashi M.D., M.S.

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引用次数: 0

摘要

人类胚胎非整倍体可能是辅助生殖技术（ART）的最后前沿之一，主要是由于卵母细胞非整倍体造成的。哺乳动物的卵母细胞具有独特的特性，使其非整倍体率远远高于精子或大多数体细胞。其中一些特性与年龄无关，而另一些特性则是生殖衰老和环境毒性的结果。对这些特性的详细了解可能会开发出新型诊断和治疗工具，用于检测和预防卵母细胞和胚胎非整倍体，从而克服人工生殖技术成功的最终障碍。

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Embryonic aneuploidy — the true “last barrier in assisted reproductive technology”?

Human embryonic aneuploidy may represent one of the final frontiers in assisted reproductive technology, primarily secondary to oocyte aneuploidy. Mammalian oocytes possess unique characteristics predisposing them to much higher rates of aneuploidy than sperm or most somatic cells. Some of these characteristics are age-independent, whereas others result from reproductive aging and environmental toxicity. A detailed understanding of these properties may lead to novel diagnostic and therapeutic tools designed to detect and prevent oocyte and embryonic aneuploidy to overcome this ultimate barrier to success in assisted reproductive technology.

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来源期刊

F&S science Endocrinology, Diabetes and Metabolism, Obstetrics, Gynecology and Women's Health, Urology

CiteScore

2.00

自引率

0.00%

发文量

审稿时长

51 days