特珠单抗与安慰剂相比，重度、未控制哮喘患者口服和吸入皮质类固醇剂量的减少来自 DESTINATION。

IF 8.2 1区医学 Q1 ALLERGY

Journal of Allergy and Clinical Immunology-In Practice Pub Date : 2024-11-01 Epub Date: 2024-08-08 DOI:10.1016/j.jaip.2024.08.008

Michael E Wechsler, Daiana Stolz, Njira L Lugogo, Scott Caveney, Gun Almqvist, Artur Bednarczyk, Ales Kotalik, Shradha Chandarana, Christopher S Ambrose

引用次数: 0

摘要

临床意义：全球哮喘倡议》建议逐步减少治疗剂量，将口服/吸入皮质类固醇的剂量降至能控制症状和加重的最低水平。与安慰剂相比，特珠单抗治疗可减少口服/吸入皮质类固醇的剂量，同时保持哮喘症状控制和肺功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Oral and inhaled corticosteroid dose reductions with tezepelumab versus placebo in patients with severe, uncontrolled asthma from DESTINATION.

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来源期刊

Journal of Allergy and Clinical Immunology-In Practice ALLERGYIMMUNOLOGY-IMMUNOLOGY

CiteScore

11.10

自引率

9.60%

发文量

683

审稿时长

50 days

期刊介绍： JACI: In Practice is an official publication of the American Academy of Allergy, Asthma & Immunology (AAAAI). It is a companion title to The Journal of Allergy and Clinical Immunology, and it aims to provide timely clinical papers, case reports, and management recommendations to clinical allergists and other physicians dealing with allergic and immunologic diseases in their practice. The mission of JACI: In Practice is to offer valid and impactful information that supports evidence-based clinical decisions in the diagnosis and management of asthma, allergies, immunologic conditions, and related diseases. This journal publishes articles on various conditions treated by allergist-immunologists, including food allergy, respiratory disorders (such as asthma, rhinitis, nasal polyps, sinusitis, cough, ABPA, and hypersensitivity pneumonitis), drug allergy, insect sting allergy, anaphylaxis, dermatologic disorders (such as atopic dermatitis, contact dermatitis, urticaria, angioedema, and HAE), immunodeficiency, autoinflammatory syndromes, eosinophilic disorders, and mast cell disorders. The focus of the journal is on providing cutting-edge clinical information that practitioners can use in their everyday practice or to acquire new knowledge and skills for the benefit of their patients. However, mechanistic or translational studies without immediate or near future clinical relevance, as well as animal studies, are not within the scope of the journal.