猪-人异种移植中免疫抑制的机遇与挑战。

IF 12.8 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Med Pub Date : 2024-08-09 DOI:10.1016/j.medj.2024.07.017

Guillaume Onyeaghala, Casey R Dorr, Ajay K Israni

引用次数: 0

摘要

器官的跨物种移植可能会缓解肾脏供体短缺的问题，使越来越多的病人能够得到肾脏移植。然而，由于异种器官移植对受者的生理和免疫影响尚未定性，这一潜力仍然受到限制，Pan 等人1 在本研究中对此进行了调查。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Opportunities and challenges for immunosuppression in the context of pig-to-human xenotransplantation.

The transplantation of organ(s) across species may alleviate the shortage of available donor kidneys for an ever-growing number of patients on transplant waiting lists. However, this potential remains limited by uncharacterized physiologic and immune effects of xenotransplants in recipients, which Pan et al.¹ investigated in the current study.

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来源期刊

Med MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

17.70

自引率

0.60%

发文量

102

期刊介绍： Med is a flagship medical journal published monthly by Cell Press, the global publisher of trusted and authoritative science journals including Cell, Cancer Cell, and Cell Reports Medicine. Our mission is to advance clinical research and practice by providing a communication forum for the publication of clinical trial results, innovative observations from longitudinal cohorts, and pioneering discoveries about disease mechanisms. The journal also encourages thought-leadership discussions among biomedical researchers, physicians, and other health scientists and stakeholders. Our goal is to improve health worldwide sustainably and ethically. Med publishes rigorously vetted original research and cutting-edge review and perspective articles on critical health issues globally and regionally. Our research section covers clinical case reports, first-in-human studies, large-scale clinical trials, population-based studies, as well as translational research work with the potential to change the course of medical research and improve clinical practice.