胰高血糖素样肽受体-1 受体激动剂：2 型糖尿病和慢性肾脏病的新兴第四支柱？

IF 12.8 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Med Pub Date : 2024-08-09 DOI:10.1016/j.medj.2024.06.010

James Ling, Elaine Chow

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引用次数: 0

摘要

此前，没有随机对照试验将胰高血糖素样肽-1 受体激动剂（GLP-1RA）的肾保护作用作为糖尿病和慢性肾病患者的主要终点进行研究。在 FLOW 试验中，Perkovic 等人的研究表明，与安慰剂相比，每周服用一次的塞马鲁肽可将肾功能衰竭、肾脏相关死亡和心血管死亡的发生率降低 24%，而安慰剂则可将肾功能衰竭、肾脏相关死亡和心血管死亡的发生率降低 24%。

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Glucagon-like peptide receptor-1 receptor agonists: The emerging fourth pillar in type 2 diabetes and chronic kidney disease?

Previously, no randomized controlled trials investigated the renoprotective effects of glucagon-like peptide-1 receptor agonists (GLP-1RA) as the primary endpoint in patients with diabetes and chronic kidney disease. In the FLOW trial, Perkovic et al. showed that once-weekly semaglutide reduced kidney failure, kidney-related death, and cardiovascular death by 24% as compared with placebo in patients with type 2 diabetes at high risk of renal progression.¹.

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来源期刊

Med MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

17.70

自引率

0.60%

发文量

102

期刊介绍： Med is a flagship medical journal published monthly by Cell Press, the global publisher of trusted and authoritative science journals including Cell, Cancer Cell, and Cell Reports Medicine. Our mission is to advance clinical research and practice by providing a communication forum for the publication of clinical trial results, innovative observations from longitudinal cohorts, and pioneering discoveries about disease mechanisms. The journal also encourages thought-leadership discussions among biomedical researchers, physicians, and other health scientists and stakeholders. Our goal is to improve health worldwide sustainably and ethically. Med publishes rigorously vetted original research and cutting-edge review and perspective articles on critical health issues globally and regionally. Our research section covers clinical case reports, first-in-human studies, large-scale clinical trials, population-based studies, as well as translational research work with the potential to change the course of medical research and improve clinical practice.