Jordi Tortosa-Carreres , Laura Cubas-Núñez , Mónica Piqueras , Jéssica Castillo-Villalba , Carlos Quintanilla-Bordàs , Ana Quiroga-Varela , Noelia Villarrubia , Enric Monreal , Gary Álvarez , Raquel Gasque-Rubio , Lorena Forés-Toribio , Sara Carratalà-Boscà , Celia Lucas , María T. Sanz , Lluís Ramió-Torrentà , Luisa María Villar , Bonaventura Casanova , Begoña Laiz , Francisco Carlos Pérez-Miralles
{"title":"评估多发性硬化症患者血清和脑脊液中的补体 C1q 水平：它能作为临床实践中的重要标记物吗？","authors":"Jordi Tortosa-Carreres , Laura Cubas-Núñez , Mónica Piqueras , Jéssica Castillo-Villalba , Carlos Quintanilla-Bordàs , Ana Quiroga-Varela , Noelia Villarrubia , Enric Monreal , Gary Álvarez , Raquel Gasque-Rubio , Lorena Forés-Toribio , Sara Carratalà-Boscà , Celia Lucas , María T. Sanz , Lluís Ramió-Torrentà , Luisa María Villar , Bonaventura Casanova , Begoña Laiz , Francisco Carlos Pérez-Miralles","doi":"10.1016/j.jneuroim.2024.578428","DOIUrl":null,"url":null,"abstract":"<div><p>Immunohistochemical studies have identified complement component C1q in MS lesions. We aimed to compare serum (sC1q) and CSF (csfC1q) levels in a large cohort of MS patients (pwMS) (<em>n</em> = 222) with those of healthy controls (HC, <em>n</em> = 52), individuals with other immune (IND, <em>n</em> = 14), and non-immune neurological disorders (nIND, <em>n</em> = 15), and to analyze their correlation with other biomarkers.</p><p>pwMS were divided into three series based on their origin. CSF samples were unavailable for HC. All three pwMS cohorts had lower sC1q levels compared to HC and IND. csfC1q was higher in one pwMS cohort, with a trend in another, and correlated with IgG, Free Kappa Light Chains, GFAP, and Chitinase-3 Like Protein-1 in CSF. Our findings suggest a significant role for C1q in MS pathophysiology, potentially serving as a biomarker for disease identification.</p></div>","PeriodicalId":16671,"journal":{"name":"Journal of neuroimmunology","volume":"394 ","pages":"Article 578428"},"PeriodicalIF":2.9000,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Evaluating the complement C1q levels in serum and cerebrospinal fluid in multiple sclerosis patients: Could it serve as a valuable marker in clinical practice?\",\"authors\":\"Jordi Tortosa-Carreres , Laura Cubas-Núñez , Mónica Piqueras , Jéssica Castillo-Villalba , Carlos Quintanilla-Bordàs , Ana Quiroga-Varela , Noelia Villarrubia , Enric Monreal , Gary Álvarez , Raquel Gasque-Rubio , Lorena Forés-Toribio , Sara Carratalà-Boscà , Celia Lucas , María T. Sanz , Lluís Ramió-Torrentà , Luisa María Villar , Bonaventura Casanova , Begoña Laiz , Francisco Carlos Pérez-Miralles\",\"doi\":\"10.1016/j.jneuroim.2024.578428\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Immunohistochemical studies have identified complement component C1q in MS lesions. We aimed to compare serum (sC1q) and CSF (csfC1q) levels in a large cohort of MS patients (pwMS) (<em>n</em> = 222) with those of healthy controls (HC, <em>n</em> = 52), individuals with other immune (IND, <em>n</em> = 14), and non-immune neurological disorders (nIND, <em>n</em> = 15), and to analyze their correlation with other biomarkers.</p><p>pwMS were divided into three series based on their origin. CSF samples were unavailable for HC. All three pwMS cohorts had lower sC1q levels compared to HC and IND. csfC1q was higher in one pwMS cohort, with a trend in another, and correlated with IgG, Free Kappa Light Chains, GFAP, and Chitinase-3 Like Protein-1 in CSF. Our findings suggest a significant role for C1q in MS pathophysiology, potentially serving as a biomarker for disease identification.</p></div>\",\"PeriodicalId\":16671,\"journal\":{\"name\":\"Journal of neuroimmunology\",\"volume\":\"394 \",\"pages\":\"Article 578428\"},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2024-08-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of neuroimmunology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0165572824001474\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"IMMUNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of neuroimmunology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0165572824001474","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
Evaluating the complement C1q levels in serum and cerebrospinal fluid in multiple sclerosis patients: Could it serve as a valuable marker in clinical practice?
Immunohistochemical studies have identified complement component C1q in MS lesions. We aimed to compare serum (sC1q) and CSF (csfC1q) levels in a large cohort of MS patients (pwMS) (n = 222) with those of healthy controls (HC, n = 52), individuals with other immune (IND, n = 14), and non-immune neurological disorders (nIND, n = 15), and to analyze their correlation with other biomarkers.
pwMS were divided into three series based on their origin. CSF samples were unavailable for HC. All three pwMS cohorts had lower sC1q levels compared to HC and IND. csfC1q was higher in one pwMS cohort, with a trend in another, and correlated with IgG, Free Kappa Light Chains, GFAP, and Chitinase-3 Like Protein-1 in CSF. Our findings suggest a significant role for C1q in MS pathophysiology, potentially serving as a biomarker for disease identification.
期刊介绍：
The Journal of Neuroimmunology affords a forum for the publication of works applying immunologic methodology to the furtherance of the neurological sciences. Studies on all branches of the neurosciences, particularly fundamental and applied neurobiology, neurology, neuropathology, neurochemistry, neurovirology, neuroendocrinology, neuromuscular research, neuropharmacology and psychology, which involve either immunologic methodology (e.g. immunocytochemistry) or fundamental immunology (e.g. antibody and lymphocyte assays), are considered for publication.
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