多酚成分 BP-C2 对小鼠生殖细胞的体内抗原毒性活性

IF 0.9 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Bulletin of Experimental Biology and Medicine Pub Date : 2024-07-01 Epub Date: 2024-08-11 DOI:10.1007/s10517-024-06182-0

A K Zhanataev, E A Anisina, A D Malikova, K L Pligina, S E Pigarev, E I Fedoros, A D Durnev, V N Anisimov

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引用次数: 0

摘要

在小鼠生殖细胞中评估了基于水解木质素多酚类化合物的 BP-C2 组合物（剂量为 60、80 和 120 毫克/千克）的体内抗原毒性活性。在小鼠卵母细胞中，BP-C2 组合物剂量依赖性地降低了拓扑异构酶 II 抑制剂依托泊苷的无性生殖活性，而不影响基因毒性物质的致畸活性。在小鼠睾丸细胞中，BP-C2 组合物降低了促氧化基因毒性物质二恶烷的 DNA 损伤活性，但不影响依托泊苷。BP-C2 成分的细胞保护活性与依托泊苷诱导的细胞毒性有关。

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Antigenotoxic Activity of Polyphenolic Composition BP-C2 in Mouse Germ Cells In Vivo.

In vivo antigenotoxic activity of BP-C2 composition (at doses of 60, 80, and 120 mg/kg) based on polyphenolic compounds derived from hydrolyzed lignin was evaluated in mouse germ cells. The BP-C2 composition dose-dependently reduced the aneugenic activity of topoisomerase II inhibitor etoposide in mouse oocytes without affecting the clastogenic activity of the genotoxicant. In mouse testicular cells, the BP-C2 composition reduced the DNA-damaging activity of the pro-oxidant genotoxicant dioxidine, but not etoposide. The cytoprotective activity of BP-C2 composition was revealed in relation to etoposide-induced cytotoxicity.

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来源期刊

Bulletin of Experimental Biology and Medicine 医学-医学：研究与实验

CiteScore

1.50

自引率

14.30%

发文量

265

审稿时长

2 months

期刊介绍： Bulletin of Experimental Biology and Medicine presents original peer reviewed research papers and brief reports on priority new research results in physiology, biochemistry, biophysics, pharmacology, immunology, microbiology, genetics, oncology, etc. Novel trends in science are covered in new sections of the journal - Biogerontology and Human Ecology - that first appeared in 2005. World scientific interest in stem cells prompted inclusion into Bulletin of Experimental Biology and Medicine a quarterly scientific journal Cell Technologies in Biology and Medicine (a new Russian Academy of Medical Sciences publication since 2005). It publishes only original papers from the leading research institutions on molecular biology of stem and progenitor cells, stem cell as the basis of gene therapy, molecular language of cell-to-cell communication, cytokines, chemokines, growth and other factors, pilot projects on clinical use of stem and progenitor cells. The Russian Volume Year is published in English from April.