不同孕期产前抑郁症状与围产期结局之间的关系:中国前瞻性多中心队列研究。

IF 3.8 4区 医学 Q1 PSYCHIATRY
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引用次数: 0

摘要

背景:有证据表明,产妇产前抑郁可能会对围产期结局产生不利影响。然而,这些研究的结果并不一致,而且主要集中在第二或第三孕期的产妇抑郁症状:这项前瞻性队列研究使用了 "中加健康生活轨迹倡议 "试验参与者的子样本。爱丁堡产后抑郁量表(EPDS)分别用于筛查第一、第二和第三孕期的抑郁症状。在婴儿出生后第一年进行了婴儿生长指标测量。结果:本研究共招募了 2053 名参与者,其中 326 人在孕期至少有一次 EPDS 评分≥10 分。在第一个孕期(aOR=1.053,95 % CI:1.004-1.103)或第二个孕期(aOR=1.060,95 % CI:1.007-1.115),EPDS 分数越高,发生巨大儿的风险越大。第三孕期 EPDS 评分越高,早产风险越高(aOR=1.079,95 % CI:1.006-1.157),婴儿胎龄偏小(aOR=1.097,95 % CI:1.015-1.185)。GEE 模型显示,怀孕三个月时 EPDS 分数越高,婴儿肩胛下皮褶厚度越大(调整后 β=0.026,95 % CI:0.003-0.050):不同孕期的产妇抑郁症状与婴儿出生时和出生后的体重和生长参数有不同的关系。本研究进一步强调了在妊娠的所有三个月(包括头三个月)进行抑郁筛查的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Associations between antenatal depressive symptoms in different trimesters and perinatal outcomes: A prospective multicenter cohort study in China

Background

Evidence exists that maternal antenatal depression may have adverse impacts on perinatal outcomes. However, the results of those studies are inconsistent and mainly focus on maternal depressive symptoms in the second or third trimester.

Methods

This prospective cohort study used a sub-sample of participants from the Sino-Canadian Healthy Life Trajectories Initiative trial. The Edinburgh Postnatal Depression Scale (EPDS) was used to screen for depressive symptoms in the first, second, and third trimesters, respectively. Infant growth indicator measurements were conducted in the first year of life. Logistic regression, Spearman correlation analyses and Generalized estimation equation (GEE) models were used to test the hypotheses.

Results

2053 participants were recruited in this study, 326 of whom had at least one EPDS score ≥ 10 during pregnancy. A higher EPDS score in the first (aOR=1.053, 95 % CI: 1.004–1.103) or in the second trimester (aOR=1.060, 95 % CI: 1.007–1.115) was associated with greater risk of macrosomia. A higher EPDS score in the third trimester was associated with higher risks of preterm birth (aOR=1.079, 95 % CI: 1.006–1.157) and the infant being small for gestational age (aOR=1.097, 95 % CI: 1.015–1.185). GEE models showed that a greater EPDS score in the third trimester was associated with higher infant subscapular skinfold thickness (adjusted β=0.026, 95 % CI: 0.003–0.050).

Conclusion

Maternal depressive symptoms in different trimesters were differentially associated with infant weight and growth parameters at birth and postnatally. The present study further highlights the importance of depression screening in all trimesters of pregnancy, including the first trimester.

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来源期刊
Asian journal of psychiatry
Asian journal of psychiatry Medicine-Psychiatry and Mental Health
CiteScore
12.70
自引率
5.30%
发文量
297
审稿时长
35 days
期刊介绍: The Asian Journal of Psychiatry serves as a comprehensive resource for psychiatrists, mental health clinicians, neurologists, physicians, mental health students, and policymakers. Its goal is to facilitate the exchange of research findings and clinical practices between Asia and the global community. The journal focuses on psychiatric research relevant to Asia, covering preclinical, clinical, service system, and policy development topics. It also highlights the socio-cultural diversity of the region in relation to mental health.
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