维生素 D 与尖锐湿疣风险的关系:一项回顾性和孟德尔随机研究。

IF 2 4区 医学 Q3 DERMATOLOGY
Yuting Cao, Xiaoying Zhou, Huan Yang
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引用次数: 0

摘要

背景:口服补充维生素D(VD)预防和治疗尖锐湿疣的临床策略有待进一步探讨:收集2018年2月至2024年6月在重庆医科大学附属儿童医院就诊的皮肤病患者的临床资料。比较尖锐湿疣(寻常疣、扁平疣、跖疣)患者与其他常见皮肤病(特应性皮炎、银屑病、斑秃、白癜风、慢性荨麻疹)患者的血清VD水平。为研究VD与尖锐湿疣之间的潜在因果关系,进行了双样本双向孟德尔随机化(MR)分析:结果:尖锐湿疣患儿的平均血清 VD 水平为 23.27 ± 7.07 ng/mL,与其他常见皮肤病患儿相比,差异无统计学意义。逆方差加权(IVW)法分析显示,VD与尖锐湿疣之间存在正向因果关系(Odds Ratio [OR] = 1.86, [95% CI: 1.19-2.92], p = 0.007)。敏感性分析未显示任何水平多向性或异质性迹象。MR-PRESSO方法未发现任何异常值:结论:与患有其他常见皮肤病的儿童相比,尖锐湿疣患儿的血清 VD 水平并没有明显下降。来自磁共振分析的证据表明,VD 与尖锐湿疣之间存在正向因果关系,因此,对于血清 VD 水平正常或升高的尖锐湿疣患儿,应谨慎补充 VD。今后还需要进一步的临床研究进行验证。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association of vitamin D with risk of warts: A retrospective and Mendelian randomization study.

Background: The clinical strategy of oral supplementation of Vitamin D (VD) as a preventive and therapeutic measure for warts needs further exploration.

Methods: The clinical data of patients with skin diseases who visited the Children's Hospital affiliated with Chongqing Medical University from February 2018 to June 2024 were collected. The serum VD levels in patients with warts (common warts, flat warts, and plantar warts) and patients with other common skin diseases (atopic dermatitis, psoriasis, alopecia areata, vitiligo, and chronic urticaria) were compared. Two-sample bidirectional Mendelian randomization (MR) analysis was performed to investigate potential causal associations between VD and warts.

Results: The average serum VD level of children with warts was 23.27 ± 7.07 ng/mL, which showed no statistically significant difference compared to children with other common skin diseases. The inverse variance weighted (IVW) method analysis indicated a positive causal relationship between VD and warts (Odds Ratio [OR] = 1.86, [95% CI: 1.19-2.92], p = 0.007). Sensitivity analysis did not show any indication of horizontal pleiotropy or heterogeneity. The MR-PRESSO method did not identify any outliers.

Conclusion: The levels of serum VD in children with warts do not significantly decrease compared to children with other common skin conditions. The evidence from the MR analysis indicates a positive causal relationship between VD and warts, suggesting caution in supplementing VD for children with warts who have normal or elevated serum VD levels. Further clinical studies are needed for validation in the future.

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来源期刊
Skin Research and Technology
Skin Research and Technology 医学-皮肤病学
CiteScore
3.30
自引率
9.10%
发文量
95
审稿时长
6-12 weeks
期刊介绍: Skin Research and Technology is a clinically-oriented journal on biophysical methods and imaging techniques and how they are used in dermatology, cosmetology and plastic surgery for noninvasive quantification of skin structure and functions. Papers are invited on the development and validation of methods and their application in the characterization of diseased, abnormal and normal skin. Topics include blood flow, colorimetry, thermography, evaporimetry, epidermal humidity, desquamation, profilometry, skin mechanics, epiluminiscence microscopy, high-frequency ultrasonography, confocal microscopy, digital imaging, image analysis and computerized evaluation and magnetic resonance. Noninvasive biochemical methods (such as lipids, keratin and tissue water) and the instrumental evaluation of cytological and histological samples are also covered. The journal has a wide scope and aims to link scientists, clinical researchers and technicians through original articles, communications, editorials and commentaries, letters, reviews, announcements and news. Contributions should be clear, experimentally sound and novel.
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