军人和退伍军人的脑外伤与睡眠:文献综述。

IF 1.7 4区 医学 Q3 CLINICAL NEUROLOGY
Jeremy Landvater, Sharon Kim, Keenan Caswell, Caroline Kwon, Emamoke Odafe, Grace Roe, Ananya Tripathi, Christian Vukovics, Jonathan Wang, Keith Ryan, Victoria Cocozza, Matthew Brock, Zahari Tchopev, Brionn Tonkin, Vincent Capaldi, Jacob Collen, Jennifer Creamer, Muna Irfan, Emerson M Wickwire, Scott Williams, J Kent Werner
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引用次数: 0

摘要

背景:创伤性脑损伤(TBI)是战时损伤的标志,与许多睡眠觉醒障碍(SWD)有关,在退伍军人中长期存在。目前在病理生理学方面的知识空白阻碍了诊断和治疗的进展:我们回顾了过去二十年中出现的 TBI SWD 病理生理学、合并症、诊断和治疗:我们对 2000 年以来发表的评估睡眠障碍(阻塞性睡眠呼吸暂停、失眠、嗜睡、寄生虫病、不安腿综合征和周期性肢体运动障碍)和创伤性脑损伤的英文文献进行了回顾。我们排除了不是专门评估创伤性脑损伤人群的研究:结果:在创伤性脑损伤的病理生理学和睡眠障碍的机制、创伤性脑损伤睡眠障碍与创伤后应激障碍睡眠障碍的比较等方面,发现了值得关注的领域和知识空白。此外,还将讨论创伤后应激障碍和血流生物标志物的作用以及创伤后应激障碍性睡眠障碍的管理策略:我们对创伤性脑损伤和睡眠健康的病理生理学基础的了解有限,尤其是在基础科学层面。对并发 TBI SWD 的生物标志物、神经影像学和混合方法研究的了解,最有希望提高我们对这一弱势群体进行诊断和监测治疗反应的能力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Traumatic brain injury and sleep in military and veteran populations: A literature review.

Background: Traumatic brain injury (TBI) is a hallmark of wartime injury and is related to numerous sleep wake disorders (SWD), which persist long term in veterans. Current knowledge gaps in pathophysiology have hindered advances in diagnosis and treatment.

Objective: We reviewed TBI SWD pathophysiology, comorbidities, diagnosis and treatment that have emerged over the past two decades.

Methods: We conducted a literature review of English language publications evaluating sleep disorders (obstructive sleep apnea, insomnia, hypersomnia, parasomnias, restless legs syndrome and periodic limb movement disorder) and TBI published since 2000. We excluded studies that were not specifically evaluating TBI populations.

Results: Highlighted areas of interest and knowledge gaps were identified in TBI pathophysiology and mechanisms of sleep disruption, a comparison of TBI SWD and post-traumatic stress disorder SWD. The role of TBI and glymphatic biomarkers and management strategies for TBI SWD will also be discussed.

Conclusion: Our understanding of the pathophysiologic underpinnings of TBI and sleep health, particularly at the basic science level, is limited. Developing an understanding of biomarkers, neuroimaging, and mixed-methods research in comorbid TBI SWD holds the greatest promise to advance our ability to diagnose and monitor response to therapy in this vulnerable population.

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来源期刊
NeuroRehabilitation
NeuroRehabilitation CLINICAL NEUROLOGY-REHABILITATION
CiteScore
3.20
自引率
0.00%
发文量
178
审稿时长
6-12 weeks
期刊介绍: NeuroRehabilitation, an international, interdisciplinary, peer-reviewed journal, publishes manuscripts focused on scientifically based, practical information relevant to all aspects of neurologic rehabilitation. We publish unsolicited papers detailing original work/research that covers the full life span and range of neurological disabilities including stroke, spinal cord injury, traumatic brain injury, neuromuscular disease and other neurological disorders. We also publish thematically organized issues that focus on specific clinical disorders, types of therapy and age groups. Proposals for thematic issues and suggestions for issue editors are welcomed.
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