{"title":"热带念珠菌皮肤感染手术与 ALA-PDT 联合治疗获得成功：病例报告与文献综述","authors":"Xian He, Yuangang Lu","doi":"10.1016/j.pdpdt.2024.104303","DOIUrl":null,"url":null,"abstract":"<div><p>Candidiasis is a common fungal infection, with Candida tropicalis infections being relatively rare. These infections develop into skin fungal infections under conditions such as broad-spectrum antibiotic use, diabetes, and immunosuppression. Traditionally, antifungal drugs have been the primary treatment; however, issues like hepatotoxicity and the need for long-term use persist. Consequently, new treatment approaches are essential. Most previous reports have focused on Candida albicans, with fewer addressing Candida tropicalis. This study reports a case where a patient with a skin Candida tropicalis infection was treated with a combination of surgery and ALA photodynamic therapy(635 nm, 120 J/cm<sup>2</sup>, 177 mW/cm<sup>2</sup>). After just one session of this combined treatment, the patient achieved significant clinical remission. Therefore, the combination of surgery and ALA-PDT may offer a safe and effective treatment option.</p></div>","PeriodicalId":20141,"journal":{"name":"Photodiagnosis and Photodynamic Therapy","volume":"49 ","pages":"Article 104303"},"PeriodicalIF":3.1000,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1572100024003405/pdfft?md5=ad3c993c74e615eaa987390d811c6dfe&pid=1-s2.0-S1572100024003405-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Successful combined treatment with surgery and ALA-PDT for cutaneous infection by candida tropicalis: A case report and literature review\",\"authors\":\"Xian He, Yuangang Lu\",\"doi\":\"10.1016/j.pdpdt.2024.104303\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Candidiasis is a common fungal infection, with Candida tropicalis infections being relatively rare. These infections develop into skin fungal infections under conditions such as broad-spectrum antibiotic use, diabetes, and immunosuppression. Traditionally, antifungal drugs have been the primary treatment; however, issues like hepatotoxicity and the need for long-term use persist. Consequently, new treatment approaches are essential. Most previous reports have focused on Candida albicans, with fewer addressing Candida tropicalis. This study reports a case where a patient with a skin Candida tropicalis infection was treated with a combination of surgery and ALA photodynamic therapy(635 nm, 120 J/cm<sup>2</sup>, 177 mW/cm<sup>2</sup>). After just one session of this combined treatment, the patient achieved significant clinical remission. Therefore, the combination of surgery and ALA-PDT may offer a safe and effective treatment option.</p></div>\",\"PeriodicalId\":20141,\"journal\":{\"name\":\"Photodiagnosis and Photodynamic Therapy\",\"volume\":\"49 \",\"pages\":\"Article 104303\"},\"PeriodicalIF\":3.1000,\"publicationDate\":\"2024-08-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S1572100024003405/pdfft?md5=ad3c993c74e615eaa987390d811c6dfe&pid=1-s2.0-S1572100024003405-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Photodiagnosis and Photodynamic Therapy\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1572100024003405\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Photodiagnosis and Photodynamic Therapy","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1572100024003405","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
念珠菌病是一种常见的真菌感染，热带念珠菌感染则相对少见。在使用广谱抗生素、糖尿病和免疫抑制等情况下，这些感染会发展成皮肤真菌感染。传统上，抗真菌药物是主要的治疗方法，但肝毒性和需要长期使用等问题依然存在。因此，新的治疗方法至关重要。以前的大多数报道都集中在白色念珠菌上，较少涉及热带念珠菌。本研究报告了一例皮肤念珠菌感染患者，患者接受了手术和 ALA 光动力疗法（635 纳米，120 焦耳/平方厘米，177 毫瓦/平方厘米）联合治疗。仅经过一个疗程的联合治疗，患者的临床症状就得到了明显缓解。因此，手术和 ALA-PDT 联合治疗可能是一种安全有效的治疗方案。
Successful combined treatment with surgery and ALA-PDT for cutaneous infection by candida tropicalis: A case report and literature review
Candidiasis is a common fungal infection, with Candida tropicalis infections being relatively rare. These infections develop into skin fungal infections under conditions such as broad-spectrum antibiotic use, diabetes, and immunosuppression. Traditionally, antifungal drugs have been the primary treatment; however, issues like hepatotoxicity and the need for long-term use persist. Consequently, new treatment approaches are essential. Most previous reports have focused on Candida albicans, with fewer addressing Candida tropicalis. This study reports a case where a patient with a skin Candida tropicalis infection was treated with a combination of surgery and ALA photodynamic therapy(635 nm, 120 J/cm2, 177 mW/cm2). After just one session of this combined treatment, the patient achieved significant clinical remission. Therefore, the combination of surgery and ALA-PDT may offer a safe and effective treatment option.
期刊介绍：
Photodiagnosis and Photodynamic Therapy is an international journal for the dissemination of scientific knowledge and clinical developments of Photodiagnosis and Photodynamic Therapy in all medical specialties. The journal publishes original articles, review articles, case presentations, "how-to-do-it" articles, Letters to the Editor, short communications and relevant images with short descriptions. All submitted material is subject to a strict peer-review process.
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