癌症中的 Cullin-RING 连接酶 4：结构、功能和机制

IF 9.7 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochimica et biophysica acta. Reviews on cancer Pub Date : 2024-08-06 DOI:10.1016/j.bbcan.2024.189169

Jingyi Cheng , Xin Bin , Zhangui Tang

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引用次数: 0

摘要

Cullin-RING ligase 4（CRL4）在各种生物和病理事件，尤其是癌症相关事件中发挥着广泛的调控作用，因而备受关注。CRL4 通过靶向各种底物进行蛋白酶体降解，或通过不同的内部组成改变活性来调控癌症进展中的各种事件，从而发挥多效应。在这篇综述中，我们总结了具有多种组成模式的 CRL4 的结构，并阐明了 CRL4 在一系列癌症相关事件中的新功能和分子机制。

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Cullin-RING Ligase 4 in Cancer: Structure, Functions, and Mechanisms

Cullin-RING ligase 4 (CRL4) has attracted enormous attentions because of its extensive regulatory roles in a wide variety of biological and pathological events, especially cancer-associated events. CRL4 exerts pleiotropic effects by targeting various substrates for proteasomal degradation or changes in activity through different internal compositions to regulate diverse events in cancer progression. In this review, we summarize the structure of CRL4 with manifold compositional modes and clarify the emerging functions and molecular mechanisms of CRL4 in a series of cancer-associated events.

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来源期刊

Biochimica et biophysica acta. Reviews on cancer 医学-生化与分子生物学

CiteScore

17.20

自引率

0.00%

发文量

138

审稿时长

33 days

期刊介绍： Biochimica et Biophysica Acta (BBA) - Reviews on Cancer encompasses the entirety of cancer biology and biochemistry, emphasizing oncogenes and tumor suppressor genes, growth-related cell cycle control signaling, carcinogenesis mechanisms, cell transformation, immunologic control mechanisms, genetics of human (mammalian) cancer, control of cell proliferation, genetic and molecular control of organismic development, rational anti-tumor drug design. It publishes mini-reviews and full reviews.