改变重力条件下的水凝胶机械特性。

IF 4.4 1区物理与天体物理 Q1 MULTIDISCIPLINARY SCIENCES

npj Microgravity Pub Date : 2024-08-08 DOI:10.1038/s41526-024-00388-2

Vanja Mišković, Immacolata Greco, Christophe Minetti, Francesca Cialdai, Monica Monici, Arianna Gazzi, Jeremiah Marcellino, Yarjan Abdul Samad, Lucia Gemma Delogu, Andrea C Ferrari, Carlo Saverio Iorio

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引用次数: 0

摘要

暴露于改变的重力环境会影响细胞培养物中的细胞行为。水凝胶是制造组织工程支架最常用的材料之一，其机械特性在细胞与基质的相互作用中起着至关重要的作用。然而，人们对重力改变对水凝胶特性的影响知之甚少。在这里，我们研究了聚（乙二醇）二丙烯酸酯（PEGDA）和聚（乙二醇）二丙烯酸酯与氧化石墨烯（GO）结合的机械性能，方法是在抛物线飞行活动中进行微重力和超重力拉伸测试，并将它们与在地球重力下进行的相同测试进行比较。结果表明，重力水平不会导致杨氏模量出现统计学上的显著差异。

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Hydrogel mechanical properties in altered gravity.

Exposure to altered gravity influences cellular behaviour in cell cultures. Hydrogels are amongst the most common materials used to produce tissue-engineering scaffolds, and their mechanical properties play a crucial role in cell-matrix interaction. However, little is known about the influence of altered gravity on hydrogel properties. Here we study the mechanical properties of Poly (ethylene glycol) diacrylate (PEGDA) and PEGDA incorporated with graphene oxide (GO) by performing tensile tests in micro and hypergravity during a Parabolic flight campaign, and by comparing them to the same tests performed in Earth gravity. We show that gravity levels do not result in a statistically significant difference in Young's modulus.

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来源期刊

npj Microgravity Physics and Astronomy-Physics and Astronomy (miscellaneous)

CiteScore

7.30

自引率

7.80%

发文量

审稿时长

9 weeks

期刊介绍： A new open access, online-only, multidisciplinary research journal, npj Microgravity is dedicated to publishing the most important scientific advances in the life sciences, physical sciences, and engineering fields that are facilitated by spaceflight and analogue platforms.