PARP1 的转录调控机制及其在疾病治疗中的应用。

IF 4.2 2区生物学 Q1 GENETICS & HEREDITY

Epigenetics & Chromatin Pub Date : 2024-08-08 DOI:10.1186/s13072-024-00550-w

Yu Lu, Wenliang Fu, Weiwei Xing, Haowei Wu, Chao Zhang, Donggang Xu

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引用次数: 0

摘要

聚（ADP-核糖）聚合酶 1（PARP1）是一种多功能核酶，在真核细胞中催化聚 ADP 核糖基化。除了维护基因组的完整性，这种核酶还参与转录调控。PARP1 可以引发和维持染色质结构的变化，并直接招募转录因子。PARP1 还能防止 DNA 甲基化。然而，以往关于 PARP1 的综述大多集中在其参与维持基因组完整性方面，而较少关注其转录调控功能。本文全面综述了 PARP1 的转录调控功能及其在疾病治疗中的应用，为靶向 PARP1 治疗癌症以外的疾病提供了新思路。

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Transcriptional regulation mechanism of PARP1 and its application in disease treatment.

Poly (ADP-ribose) polymerase 1 (PARP1) is a multifunctional nuclear enzyme that catalyzes poly-ADP ribosylation in eukaryotic cells. In addition to maintaining genomic integrity, this nuclear enzyme is also involved in transcriptional regulation. PARP1 can trigger and maintain changes in the chromatin structure and directly recruit transcription factors. PARP1 also prevents DNA methylation. However, most previous reviews on PARP1 have focused on its involvement in maintaining genome integrity, with less focus on its transcriptional regulatory function. This article comprehensively reviews the transcriptional regulatory function of PARP1 and its application in disease treatment, providing new ideas for targeting PARP1 for the treatment of diseases other than cancer.

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来源期刊

Epigenetics & Chromatin GENETICS & HEREDITY-

CiteScore

7.00

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： Epigenetics & Chromatin is a peer-reviewed, open access, online journal that publishes research, and reviews, providing novel insights into epigenetic inheritance and chromatin-based interactions. The journal aims to understand how gene and chromosomal elements are regulated and their activities maintained during processes such as cell division, differentiation and environmental alteration.