R Keerthika, Anju Devi, Mala Kamboj, Anjali Narwal
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The data obtained were analyzed using Chi-square, Spearman's correlation test and multiple regression analysis (<i>p</i> < 0.05).</p><p><strong>Results: </strong>CCs were present significantly in various grades of OSCC (<i>p</i> < 0.00). Immunohistochemical analysis revealed a significant difference in CD68, BCL2 (<i>p</i> < 0.05 in both), and CD31 (<i>p</i> < 0.001) expression with CC. The internalized cells showed positivity for CD68 and negativity for BCL2. Regression analysis revealed that tumor grade, CD31 and BCL2 immunoreactivity were significant predictors of frequency of CC.</p><p><strong>Conclusion: </strong>The association of CC with degree of differentiation, CD31, CD68, and BCL2 expression could predict the biological behavior of OSCC and might serve as a promising histopathological parameter in future.</p>","PeriodicalId":47495,"journal":{"name":"Journal of Maxillofacial & Oral Surgery","volume":"23 4","pages":"881-889"},"PeriodicalIF":0.8000,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11303648/pdf/","citationCount":"0","resultStr":"{\"title\":\"Association of Cellular Cannibalism with Immunohistochemical Expression of CD31, CD68 and BCL2 in Oral Squamous Cell Carcinoma: An Observational Study.\",\"authors\":\"R Keerthika, Anju Devi, Mala Kamboj, Anjali Narwal\",\"doi\":\"10.1007/s12663-024-02217-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>Cellular cannibalism (CC) is a prime metabolic event to determine the aggressive potential of oral squamous cell carcinoma (OSCC). 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引用次数: 0
摘要
目的：细胞食人（CC）是决定口腔鳞状细胞癌（OSCC）侵袭潜力的主要代谢事件。然而，这种退化背后的病因和机制仍不明确。本研究旨在探索CC背后的病因机制，以及它与OSCC的分化程度、血管生成、吞噬细胞和抗凋亡活性之间的关联：设计：从科室档案中提取了73张不同组织学级别的OSCC组织切片，并对其进行了食人细胞扫描。使用 CD31、CD68 和 BCL2 进行免疫组化分析。利用卡方检验（Chi-square）、斯皮尔曼相关检验（Spearman's correlation test）和多元回归分析（p Results：不同分级的 OSCC 中均存在明显的 CC（p p p 结论：CC 与分化程度相关：CC与分化程度、CD31、CD68和BCL2表达的相关性可预测OSCC的生物学行为，未来可作为一种有前途的组织病理学参数。
Association of Cellular Cannibalism with Immunohistochemical Expression of CD31, CD68 and BCL2 in Oral Squamous Cell Carcinoma: An Observational Study.
Objective: Cellular cannibalism (CC) is a prime metabolic event to determine the aggressive potential of oral squamous cell carcinoma (OSCC). However, the etiology and mechanism behind this degradation are still ambiguous. The aim of the study was to explore the etiopathogenetic mechanism behind CC, along with its association with degree of differentiation, angiogenic, phagocytic and antiapoptotic activity in OSCC.
Design: Seventy-three tissue sections of various histological grades of OSCC were retrieved from departmental archives and scanned for cannibalistic cells. Immunohistochemical analysis using CD31, CD68, and BCL2 was performed. The data obtained were analyzed using Chi-square, Spearman's correlation test and multiple regression analysis (p < 0.05).
Results: CCs were present significantly in various grades of OSCC (p < 0.00). Immunohistochemical analysis revealed a significant difference in CD68, BCL2 (p < 0.05 in both), and CD31 (p < 0.001) expression with CC. The internalized cells showed positivity for CD68 and negativity for BCL2. Regression analysis revealed that tumor grade, CD31 and BCL2 immunoreactivity were significant predictors of frequency of CC.
Conclusion: The association of CC with degree of differentiation, CD31, CD68, and BCL2 expression could predict the biological behavior of OSCC and might serve as a promising histopathological parameter in future.
期刊介绍：
This journal offers comprehensive coverage of new techniques, important developments and innovative ideas in Oral and Maxillofacial Surgery. Practice-applicable articles help develop the methods used to handle dentoalveolar surgery, facial injuries and deformities, TMJ disorders, oral cancer, jaw reconstruction, anesthesia and analgesia. The journal also includes specifics on new instruments, diagnostic equipment’s and modern therapeutic drugs and devices. Journal of Oral and Maxillofacial Surgery is recommended for first or priority subscription by the Dental Section of the Medical Library Association. Specific topics covered recently have included: ? distraction osteogenesis ? synthetic bone substitutes ? fibroblast growth factors ? fetal wound healing ? skull base surgery ? computer-assisted surgery ? vascularized bone grafts Benefits to authorsWe also provide many author benefits, such as free PDFs, a liberal copyright policy, special discounts on Elsevier publications and much more. Please click here for more information on our author services.
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