胰腺癌风险与脂肪组织和尿液中有机氯农药浓度之间的关系:一项有针对性的筛查分析病例对照研究(PESTIPAC)。

IF 5.8 2区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY
United European Gastroenterology Journal Pub Date : 2024-09-01 Epub Date: 2024-08-08 DOI:10.1002/ueg2.12602
Mathias Brugel, Sidonie Callon, Claire Carlier, Koceila Lamine Amroun, Damien Botsen, Reza Kianmanesh, Marine Perrier, Tullio Piardi, Yohann Renard, Rami Rhaiem, Souleiman El Balkhi, Olivier Bouché
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引用次数: 0

摘要

背景:有关环境因素(包括农药暴露)导致胰腺腺癌(PA)的知识仍然有限。有机氯(OC)会积聚在脂肪组织中,有助于反映长期暴露情况:PA患者的年龄和体重指数(BMI)与良性疾病手术患者的年龄和体重指数(1:1)相匹配。有针对性的分析筛查了脂肪组织和尿液样本中的 345 种农药和代谢物,包括 29 种 OC。主要目的是研究内脏脂肪或尿液中的有机氯浓度与 PA 之间的关系。在考虑多重检验的情况下,进行了调整条件逻辑回归:结果:反式壬草胺(比值比 [OR] = 1.325,95% 置信区间 [CI] [1.108-1.586])、顺式壬草胺(比值比 [OR] = 15.433,95% 置信区间 [2.733-87.136])、灭蚁灵(比值比 [OR] = 2.853,95% 置信区间 [1.213-6.脂肪中的 4,4-DDE(OR = 1.019,95% CI [1.005-1.034])和更多的阳性样本(OR = 1.758 95% CI [1.11-2.997])与 PA 的几率显著相关。与此相反,尿液样本与所有受测农药均无统计学意义上的关联:结论:某些 OC 与 PA 发生几率较高有关。结论:某些 OC 与胰腺侵犯的几率较高有关,需要对胰腺侵犯的潜在机制进行研究,以完善这些发现:试验注册:Clinicaltrials.gov NCT04429490。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association between pancreatic adenocarcinoma risk and concentration of organochlorine pesticides in adipose tissue and urine: A targeted-screening analysis case-control study (PESTIPAC).

Background: Knowledge about environmental pancreatic adenocarcinoma (PA) risk factors, including pesticide exposure, remains limited. Organochlorine (OC) accumulates in adipose tissue and can help reflect long-term exposure.

Patients and methods: Age and body mass index (BMI) of patients with PA were matched with those undergoing a surgery for a benign disease on age and BMI (1:1). Targeted analyses screened 345 pesticides and metabolites, including 29 OC, in adipose tissue and urine samples. The primary aim was to investigate the association between organochlorine concentrations in visceral fat or urine, and PA. Adjusted conditional logistic regressions were carried out accounting for multiple testing.

Results: Trans-nonachlor (odds ratio [OR] = 1.325, 95% confidence interval [CI] [1.108-1.586]), cis-nonachlor (OR = 15.433, 95% CI [2.733-87.136]), Mirex (OR = 2.853, 95% CI [1.213-6.713]) and 4,4 DDE (OR = 1.019, 95% CI [1.005-1.034]) in fat and a greater number of positive samples (OR = 1.758 95% CI [1.11-2.997]) were significantly associated with higher odds of PA. In contrast, as awaited, urine samples did not yield any statistically significant associations for all tested pesticides.

Conclusion: Some OCs were associated with higher odds of PA. The underlying mechanisms of pancreatic aggression need to be investigated to refine these findings.

Trial registration: Clinicaltrials.gov NCT04429490.

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来源期刊
United European Gastroenterology Journal
United European Gastroenterology Journal GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
10.50
自引率
13.30%
发文量
147
期刊介绍: United European Gastroenterology Journal (UEG Journal) is the official Journal of the United European Gastroenterology (UEG), a professional non-profit organisation combining all the leading European societies concerned with digestive disease. UEG’s member societies represent over 22,000 specialists working across medicine, surgery, paediatrics, GI oncology and endoscopy, which makes UEG a unique platform for collaboration and the exchange of knowledge.
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