体重指数与过去 8 周内确诊感染 COVID-19 的未接种疫苗成人的血小板活化和炎症生物标志物的急性期后升高有关。

IF 3.9 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Obesity Facts Pub Date : 2024-08-08 DOI:10.1159/000540343

Samantha N Fessler, Li Liu, Yung Chang, Carol S Johnston

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引用次数: 0

摘要

肥胖已成为COVID-19严重程度和Long COVID（LC）的一个突出风险因素，部分原因可能是肥胖导致的促炎状态：本研究旨在探讨最近被诊断为 COVID-19 的非住院成年人体内循环炎症生物标志物与体重指数之间的关系：本分析包括完成 2020 年 10 月至 2021 年 3 月随机安慰剂对照试验的参与者。参与者（19-53 岁）在确诊 COVID-19 后未接种疫苗，并在疾病预防控制中心重返工作岗位指南允许的情况下参加了试验。在研究基线和第四周对人体测量和生物标志物进行评估。我们通过多元回归模型研究了体重指数与炎症生物标志物之间的关系：研究基线（即结果：在所有参与者（N=60）的研究基线（即 COVID-19 诊断后的入组点）上，较高的 BMI 与多种炎症生物标志物的升高有关，包括 IL-6 (β=7.63, 95%CI= 3.54, 11.89, p = 0.0004)、铁蛋白 (β= 6.31, 95%CI= 1.97,10.83, p = 0.0047)。83，p=0.0047）、hsCRP（β=13.1，95%CI=8.03，18.42，p=<0.0001）、TNF-α（β=3.23，95%CI=0.91，5.60，p=0.0069）、IL-12p40（β=3.69，95%CI=0.93,6.52，p=0.0094）、IL-13（β=5.11，95%CI=1.00,9.40，p=0.0154）和IL-1Ra（β=7.57，95%CI=3.61,11.70，p=0.0003）。在四周后的对照组参与者（n=30）中，较高的体重指数与IL-4（β=17.8，95%CI=0.84,37.6，p=0.0397）和sP-选择素（β=1.16，95%CI=0.22,2.11，p=0.0182）的升高相关，控制了基线和协变量：在此，体重指数与新近诊断为 COVID-19 的成年人四周后血小板活化和炎症的循环生物标志物呈正相关。本文指出，急性 COVID-19 后炎症生物标志物的变化与 BMI 的增加有关，这与文献报道的 LC 生物标志物有相似之处。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Body Mass Index Is Associated with Post-Acute Elevations in Biomarkers of Platelet Activation and Inflammation in Unvaccinated Adults Diagnosed with COVID-19 in the Previous 8 Weeks.

Introduction: Obesity has arisen as a prominent risk factor for COVID-19 severity and long COVID, potentially owed in part to the obesity-induced proinflammatory state. This study aimed to examine relationships among circulating inflammatory biomarkers and body mass index in nonhospitalized adults recently diagnosed with COVID-19.

Methods: This analysis included participants who completed a randomized placebo-controlled trial conducted in October 2020-March 2021. Participants (19-53 years) were unvaccinated and enrolled following COVID-19 diagnosis as allowed by CDC return-to-work guidance. Anthropometrics and biomarkers were assessed at study baseline and week four. We examined the associations between body mass index (BMI) and inflammatory biomarkers via multiple regression models.

Results: At study baseline (i.e., the point of enrollment following COVID-19 diagnosis) across all participants (N = 60), a higher BMI was associated with elevations in several inflammatory biomarkers including IL-6 (β = 7.63, 95% CI = 3.54, 11.89, p = 0.0004), ferritin (β = 6.31, 95% CI = 1.97, 10.83, p = 0.0047), high sensitivity C-reactive protein (β = 13.1, 95% CI = 8.03, 18.42, p = < 0.0001), tumor necrosis factor-α (β = 3.23, 95% CI = 0.91, 5.60, p = 0.0069), IL-12p40 (β = 3.69, 95% CI = 0.93, 6.52, p = 0.0094), IL-13 (β = 5.11, 95% CI = 1.00, 9.40, p = 0.0154), and IL-1Ra (β = 7.57, 95% CI = 3.61, 11.70, p = 0.0003). In control group participants (n = 30) after 4 weeks, a higher BMI was associated with elevations in IL-4 (β = 17.8, 95% CI = 0.84, 37.6, p = 0.0397) and sP-selectin (β = 1.16, 95% CI = 0.22, 2.11, p = 0.0182), controlling for baseline and covariates.

Conclusions: Here, BMI was positively associated with circulating biomarkers of platelet activation and inflammation in adults recently diagnosed with COVID-19 after 4 weeks. The shift in post-acute COVID-19 inflammatory biomarkers associated with an increasing BMI noted here shares similarities to biomarkers of LC reported in the literature.

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来源期刊

Obesity Facts 医学-内分泌学与代谢

CiteScore

6.80

自引率

5.60%

发文量

审稿时长

6-12 weeks

期刊介绍： ''Obesity Facts'' publishes articles covering all aspects of obesity, in particular epidemiology, etiology and pathogenesis, treatment, and the prevention of adiposity. As obesity is related to many disease processes, the journal is also dedicated to all topics pertaining to comorbidity and covers psychological and sociocultural aspects as well as influences of nutrition and exercise on body weight. The editors carefully select papers to present only the most recent findings in clinical practice and research. All professionals concerned with obesity issues will find this journal a most valuable update to keep them abreast of the latest scientific developments.