Radhika Sriram, Padmamalini Mahendradas, Prathiba Hande, Aditya Patil, Ankush Kawali, Sai Bhakti Mishra, Sara Rizvi, Rohit Shetty
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引用次数: 0
摘要
目的：报告一例 HIV 相关性双侧 CMV 视网膜炎患者的血清转换病例，以及在 HIV 晚期发现这一现象所面临的挑战：方法：回顾性单病例报告：结果：患者发病时的临床表现提示病毒性视网膜炎。PCR确诊为CMV视网膜炎。HIV-1 和 2 血清学检测呈阴性。HIV 病毒载量和 CD-4 细胞计数证实其血清 HIV 阳性。在对 CMV 和 HIV 进行抗病毒治疗后，视力有所改善，病变也慢慢消退。再次进行的 HIV-1 检测呈阳性，CD4 细胞计数也有所改善：结论：对于艾滋病毒血清学（筛查后检测）呈阴性的高度可疑患者，应通过检测艾滋病毒病毒载量和 CD4 细胞计数来确认疾病状态。
Seroreversion in HIV-Associated Bilateral CMV Retinitis: A Challenging Case Report.
Purpose: To report a case of seroreversion in a patient with HIV-associated bilateral CMV retinitis and the challenges associated with detection of this phenomenon in late stages of HIV.
Method: Retrospective single case report.
Results: The clinical picture of the patient on presentation was suggestive of viral retinitis. PCR confirmed a diagnosis of CMV retinitis. Serology for HIV-1 & 2 was negative. A viral load of HIV and CD-4 count confirmed his sero status to be positive for HIV. Improvement in visual acuity and slow resolution of the lesion was noted with both anti-viral for CMV and HIV. A repeat HIV-1 testing was positive with an improvement in CD4 count.
Conclusion: In highly suspicious individual, with a negative serology (post screening test) for HIV, the disease status should be confirmed by testing the individual for HIV viral load and CD4 count.
期刊介绍：
Ocular Immunology & Inflammation ranks 18 out of 59 in the Ophthalmology Category.Ocular Immunology and Inflammation is a peer-reviewed, scientific publication that welcomes the submission of original, previously unpublished manuscripts directed to ophthalmologists and vision scientists. Published bimonthly, the journal provides an international medium for basic and clinical research reports on the ocular inflammatory response and its control by the immune system. The journal publishes original research papers, case reports, reviews, letters to the editor, meeting abstracts, and invited editorials.
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