小核 RNA 机制及其在 DNA 损伤反应中作用的研究进展。

IF 16.7 2区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Li-Ping Shen, Wen-Cheng Zhang, Jia-Rong Deng, Zhen-Hua Qi, Zhong-Wu Lin, Zhi-Dong Wang
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引用次数: 0

摘要

小核糖体 RNA(snoRNA)以前被认为是一类功能保守的看家基因,主要参与核糖体 RNA(rRNA)修饰对核糖体生物发生的调控。然而,其中一些通过复杂的分子机制参与了多个生物过程。DNA 损伤应答(DDR)是维持基因组稳定性以防止各种人类疾病发生的一种保守机制。最近有研究发现,snoRNA 在多个水平上参与了 DDR,这表明它们在这一领域具有相关的理论和临床意义。本综述系统阐述了四个要点,包括 snoRNA 的生物合成和分类、snoRNA 调控靶分子的机制、snoRNA 在 DDR 过程中的作用以及 snoRNA 在疾病诊断和治疗中的意义。该研究重点关注 snoRNA 在 DDR 中的潜在功能,以帮助发现 snoRNA 在维持基因组稳定性和病理过程中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Advances in the mechanism of small nucleolar RNA and its role in DNA damage response.

Small nucleolar RNAs (snoRNAs) were previously regarded as a class of functionally conserved housekeeping genes, primarily involved in the regulation of ribosome biogenesis by ribosomal RNA (rRNA) modification. However, some of them are involved in several biological processes via complex molecular mechanisms. DNA damage response (DDR) is a conserved mechanism for maintaining genomic stability to prevent the occurrence of various human diseases. It has recently been revealed that snoRNAs are involved in DDR at multiple levels, indicating their relevant theoretical and clinical significance in this field. The present review systematically addresses four main points, including the biosynthesis and classification of snoRNAs, the mechanisms through which snoRNAs regulate target molecules, snoRNAs in the process of DDR, and the significance of snoRNA in disease diagnosis and treatment. It focuses on the potential functions of snoRNAs in DDR to help in the discovery of the roles of snoRNAs in maintaining genome stability and pathological processes.

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来源期刊
Military Medical Research
Military Medical Research Medicine-General Medicine
CiteScore
38.40
自引率
2.80%
发文量
485
审稿时长
8 weeks
期刊介绍: Military Medical Research is an open-access, peer-reviewed journal that aims to share the most up-to-date evidence and innovative discoveries in a wide range of fields, including basic and clinical sciences, translational research, precision medicine, emerging interdisciplinary subjects, and advanced technologies. Our primary focus is on modern military medicine; however, we also encourage submissions from other related areas. This includes, but is not limited to, basic medical research with the potential for translation into practice, as well as clinical research that could impact medical care both in times of warfare and during peacetime military operations.
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