微RNA变异对三阴性乳腺癌PI3K/AKT信号转导的影响:综合综述。

IF 2.8 4区 医学 Q2 ONCOLOGY
Ehsan Mehrtabar, Amirreza Khalaji, Mojtaba Pandeh, Aram Farhoudian, Nadia Shafiee, Atefe Shafiee, Fatemeh Ojaghlou, Parinaz Mahdavi, Mehdi Soleymani-Goloujeh
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引用次数: 0

摘要

乳腺癌(BC)是导致癌症相关死亡的重要原因,而三阴性乳腺癌(TNBC)是一种侵袭性特别强的亚型,死亡率很高,尤其是在年轻女性中。TNBC 因其侵袭性肿瘤行为和有限的治疗方案而构成了相当大的临床挑战。PI3K/AKT通路的畸变在TNBC中很普遍,并与治疗干预耐药性的增加和不良预后相关。微RNA(miRs)已成为PI3K/AKT通路的重要调节因子,影响着TNBC发病机制中的各种细胞过程。包括miR-193、miR-4649-5p和miR-449a在内的miRs水平在TNBC肿瘤组织中发生了显著变化,强调了它们在癌症生物学中的重要性。本综述探讨了 TNBC 中 miR 变异与 PI3K/AKT 信号转导之间错综复杂的相互作用。综述重点探讨了 miR 介导的该通路失调的分子机制,并强调了特定的 miR 及其靶点。此外,我们还探讨了 miR 失调在 TNBC 中的临床意义,特别是它与 TNBC 预后和治疗耐药性的相关性。阐明 miRs 在调节 PI3K/AKT 信号通路中的作用将加深我们对 TNBC 生物学的理解,并揭示潜在的治疗靶点。本综述旨在讨论现有知识,为未来研究开辟前景广阔的途径,最终促进 TNBC 患者精确有效治疗方法的开发。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Impact of microRNA variants on PI3K/AKT signaling in triple-negative breast cancer: comprehensive review.

Impact of microRNA variants on PI3K/AKT signaling in triple-negative breast cancer: comprehensive review.

Breast cancer (BC) is a significant cause of cancer-related mortality, and triple-negative breast cancer (TNBC) is a particularly aggressive subtype associated with high mortality rates, especially among younger females. TNBC poses a considerable clinical challenge due to its aggressive tumor behavior and limited therapeutic options. Aberrations within the PI3K/AKT pathway are prevalent in TNBC and correlate with increased therapeutic intervention resistance and poor outcomes. MicroRNAs (miRs) have emerged as crucial PI3K/AKT pathway regulators influencing various cellular processes involved in TNBC pathogenesis. The levels of miRs, including miR-193, miR-4649-5p, and miR-449a, undergo notable changes in TNBC tumor tissues, emphasizing their significance in cancer biology. This review explored the intricate interplay between miR variants and PI3K/AKT signaling in TNBC. The review focused on the molecular mechanisms underlying miR-mediated dysregulation of this pathway and highlighted specific miRs and their targets. In addition, we explore the clinical implications of miR dysregulation in TNBC, particularly its correlation with TNBC prognosis and therapeutic resistance. Elucidating the roles of miRs in modulating the PI3K/AKT signaling pathway will enhance our understanding of TNBC biology and unveil potential therapeutic targets. This comprehensive review aims to discuss current knowledge and open promising avenues for future research, ultimately facilitating the development of precise and effective treatments for patients with TNBC.

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来源期刊
Medical Oncology
Medical Oncology 医学-肿瘤学
CiteScore
4.20
自引率
2.90%
发文量
259
审稿时长
1.4 months
期刊介绍: Medical Oncology (MO) communicates the results of clinical and experimental research in oncology and hematology, particularly experimental therapeutics within the fields of immunotherapy and chemotherapy. It also provides state-of-the-art reviews on clinical and experimental therapies. Topics covered include immunobiology, pathogenesis, and treatment of malignant tumors.
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