重新审视使用抗抑郁药与肺癌风险之间的关联。

IF 4.5 3区医学 Q1 CLINICAL NEUROLOGY

Journal of Psychopharmacology Pub Date : 2024-09-01 Epub Date: 2024-08-08 DOI:10.1177/02698811241268887

Ching-Fang Sun, Kuan-Pin Su, Anita S Kablinger

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引用次数: 0

摘要

观察性研究表明，抗抑郁药与肺癌风险增加之间可能存在相关性。然而，现有研究受限于样本量小、未调整协变量（尤其是吸烟状况）以及暴露持续时间不明确等因素。我们进行了一项大规模的回顾性队列研究，以重新审视这种关联。我们对非吸烟者和吸烟者分别进行了分析，以消除吸烟状态的混杂影响。我们发现长期服用抗抑郁药的患者罹患肺癌的风险较低，无论是吸烟者还是非吸烟者（几率比（OR）：0.61；95% CI：0.46-0.80，OR：0.75；95% CI：0.65-0.86）。没有一种抗抑郁药与肺癌风险增加有关。

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Re-visiting the association between antidepressant use and the risk of lung cancer.

Observational studies suggest a potential correlation between antidepressants and increased lung cancer risks. However, existing studies are limited to small sample sizes, unadjusted covariates especially smoking status, and unclear exposure duration. We performed a large-scale retrospective cohort study to re-examine the association. We analyzed non-smokers and smokers separately to eliminate the confounding effect of smoking status. We found patients with long-term antidepressant use were at a lower risk of lung cancer in both smokers and non-smokers (odds ratio (OR), 0.61; 95% CI: 0.46-0.80, OR: 0.75; 95% CI: 0.65-0.86). None of the antidepressants was associated with an increased lung cancer risk.

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来源期刊

Journal of Psychopharmacology 医学-精神病学

CiteScore

8.60

自引率

4.90%

发文量

126

审稿时长

3-8 weeks

期刊介绍： The Journal of Psychopharmacology is a fully peer-reviewed, international journal that publishes original research and review articles on preclinical and clinical aspects of psychopharmacology. The journal provides an essential forum for researchers and practicing clinicians on the effects of drugs on animal and human behavior, and the mechanisms underlying these effects. The Journal of Psychopharmacology is truly international in scope and readership.