混合性主动脉瓣病变中左心房和心室耦合的改变

IF 6.7 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS
Maala Sooriyakanthan, Fraser J Graham, Natalie Ho, Howard Leong-Poi, Wendy Tsang
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引用次数: 0

摘要

目的:分析中度混合型主动脉瓣病变(MMAVD)患者的左心房(LA)和左心室(LV)功能及房室耦合,与孤立的中度或重度主动脉瓣病变患者及对照组进行对比:对260例患者(46例MMAVD、81例中度主动脉瓣狭窄(AS)、50例重度AS、48例中度主动脉瓣反流(AR)和35例重度AR)和66例对照组进行了LA和LV峰值纵向应变(LS)回顾性分析。通过合并 LA 和 LV 的峰值应变评估 LV 和 LA LS 的峰值和房室耦合,并在各组之间进行比较。采用方差分析和双侧 t 检验,P 值为结论:MMAVD患者与严重孤立性AS或AR患者的房室耦合受损程度相当。MMAVD 患者左心室 GLS 的损伤反映了严重 AS 患者的损伤。这些发现表明,MMAVD 和孤立性重症患者的血流动力学后果和不良重塑相似。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Alterations in left atrial and left ventricular coupling in mixed aortic valve disease.

Aims: To characterize left atrial (LA) and left ventricular (LV) function and atrioventricular (AV) coupling in patients with moderate mixed aortic valve disease (MMAVD) against those with isolated moderate or severe aortic valve disease and controls.

Methods and results: Retrospective LA and LV peak longitudinal strain (LS) analysis were performed on 260 patients [46 MMAVD, 81 moderate aortic stenosis (AS), 50 severe AS, 48 moderate aortic regurgitation (AR), and 35 severe AR] and 66 controls. Peak LV and LA LS and AV coupling, assessed by combined peak LA and LV strain, was compared between the groups. Analysis of variance and two-sided t-tests were used, and a P-value of <0.01 was considered significant. LV strain was significantly lower in those with MMAVD compared with controls and those with moderate or severe isolated AR but comparable to those with moderate or severe AS (-17.1 ± 1.1% MMAVD vs. -17.7 ± 1.5% moderate AS, P = 0.02, vs. -17.0 ± 1.5% severe AS, P = 0.74). AV coupling was significantly lower in those with MMAVD compared with controls and those with moderate AS or AR but comparable to those with severe AS or AR (47.1 ± 6.8% MMAVD vs. 45.1 ± 5.6% severe AS, P = 0.13, vs. 50.4 ± 9% severe AR, P = 0.07).

Conclusion: Impairments in AV coupling are comparable for patients with MMAVD and those with severe isolated AS or AR. Impairments in LV GLS in MMAVD mirror those found in severe AS. These findings suggest that haemodynamic consequences and adverse remodelling are similar for patients with MMAVD and isolated severe disease.

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来源期刊
European Heart Journal - Cardiovascular Imaging
European Heart Journal - Cardiovascular Imaging CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
11.60
自引率
9.70%
发文量
708
审稿时长
4-8 weeks
期刊介绍: European Heart Journal – Cardiovascular Imaging is a monthly international peer reviewed journal dealing with Cardiovascular Imaging. It is an official publication of the European Association of Cardiovascular Imaging, a branch of the European Society of Cardiology. The journal aims to publish the highest quality material, both scientific and clinical from all areas of cardiovascular imaging including echocardiography, magnetic resonance, computed tomography, nuclear and invasive imaging. A range of article types will be considered, including original research, reviews, editorials, image focus, letters and recommendation papers from relevant groups of the European Society of Cardiology. In addition it provides a forum for the exchange of information on all aspects of cardiovascular imaging.
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