外周 T 细胞淋巴瘤患者中 Ras 同源家族成员 A 的突变及其对个性化医疗的影响。

IF 5.6 2区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
Lina Hu, Xuanye Zhang, Shengbing Zang
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引用次数: 0

摘要

基因组测序发现,Ras同源家族成员A(RHOA)在各种癌症中频繁发生突变,具有独特的异常特征和致病作用,尤其是在外周T细胞淋巴瘤(PTCL)中。肿瘤类型不同,RHOA 氨基酸置换的离散位置分布和类型也不同,从而导致不同的功能和生物学特性,这为各种肿瘤的分子发病机制和潜在靶向治疗提供了新的视角。然而,不同组织学亚型的PTCL在RHOA突变特征上的异同尚未完全阐明。在此,我们强调了RHOA突变类型和位置的不一致性和复杂性,并证明了RHOA变异通过结合表观遗传学异常和激活多种下游通路对PTCL发病机制的贡献。此外,还概述了将 RHOA 作为靶向治疗方法的巨大潜力。这篇综述为个性化医疗领域提供了新的见解,以改善患者的临床疗效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mutations in Ras homolog family member A in patients with peripheral T-cell lymphoma and implications for personalized medicine.

Genome sequencing has revealed frequent mutations in Ras homolog family member A (RHOA) among various cancers with unique aberrant profiles and pathogenic effects, especially in peripheral T-cell lymphoma (PTCL). The discrete positional distribution and types of RHOA amino acid substitutions vary according to the tumor type, thereby leading to different functional and biological properties, which provide new insight into the molecular pathogenesis and potential targeted therapies for various tumors. However, the similarities and discrepancies in characteristics of RHOA mutations among various histologic subtypes of PTCL have not been fully elucidated. Herein we highlight the inconsistencies and complexities of the type and location of RHOA mutations and demonstrate the contribution of RHOA variants to the pathogenesis of PTCL by combining epigenetic abnormalities and activating multiple downstream pathways. The promising potential of targeting RHOA as a therapeutic modality is also outlined. This review provides new insight in the field of personalized medicine to improve the clinical outcomes for patients.

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来源期刊
Cancer Biology & Medicine
Cancer Biology & Medicine Medicine-Oncology
CiteScore
9.80
自引率
3.60%
发文量
1143
审稿时长
12 weeks
期刊介绍: Cancer Biology & Medicine (ISSN 2095-3941) is a peer-reviewed open-access journal of Chinese Anti-cancer Association (CACA), which is the leading professional society of oncology in China. The journal quarterly provides innovative and significant information on biological basis of cancer, cancer microenvironment, translational cancer research, and all aspects of clinical cancer research. The journal also publishes significant perspectives on indigenous cancer types in China.
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