转录突变：从基本原理到新见解。

IF 3.8 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochemical Society transactions Pub Date : 2024-08-28 DOI:10.1042/BST20231286

Daniel Hebenstreit, Pradip Karmakar

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引用次数: 0

摘要

转录以不规则的爆发形式出现在非常广泛的系统中，包括许多不同的物种和这些物种中的许多基因。在这篇综述中，我们研究了相关理论，讨论了这些理论与实验测量之间的关系，并探讨了不同研究之间出现的一些差异。最后，我们还将探讨整合了新概念的最新研究成果，如生物分子凝聚体参与增强子-启动子相互作用及其对转录猝发动态的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Transcriptional bursting: from fundamentals to novel insights.

Transcription occurs as irregular bursts in a very wide range of systems, including numerous different species and many genes within these. In this review, we examine the underlying theories, discuss how these relate to experimental measurements, and explore some of the discrepancies that have emerged among various studies. Finally, we consider more recent works that integrate novel concepts, such as the involvement of biomolecular condensates in enhancer-promoter interactions and their effects on the dynamics of transcriptional bursting.

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来源期刊

Biochemical Society transactions 生物-生化与分子生物学

CiteScore

7.80

自引率

0.00%

发文量

351

审稿时长

3-6 weeks

期刊介绍： Biochemical Society Transactions is the reviews journal of the Biochemical Society. Publishing concise reviews written by experts in the field, providing a timely snapshot of the latest developments across all areas of the molecular and cellular biosciences. Elevating our authors’ ideas and expertise, each review includes a perspectives section where authors offer comment on the latest advances, a glimpse of future challenges and highlighting the importance of associated research areas in far broader contexts.