容积性肌肉缺损损伤后的序贯抗纤维化治疗和康复。

IF 5.8 3区医学 Q1 DERMATOLOGY

Advances in wound care Pub Date : 2024-09-05 DOI:10.1089/wound.2024.0109

Peter R Nicholson, Christiana J Raymond-Pope, Thomas J Lillquist, Angela S Bruzina, Jarrod A Call, Sarah M Greising

引用次数: 0

摘要

目的：减轻局部病理纤维组织沉积是体积性肌肉萎缩（VML）的一个目标领域；宁替达尼有望减轻 VML 后的纤维化。本研究探讨了在 VML 术后立即进行抗纤维化治疗和延迟康复治疗如何改善 VML 术后的功能恢复。研究方法成年雄性C57BL/6小鼠（n=36）为VML损伤或Naïve小鼠，随机分配给宁替丹尼（6毫克/千克/天）治疗2周或不治疗；此外，从2周开始让小鼠使用跑步轮，直到8周。最后，除了对肌肉胶原蛋白含量、纤维化和肌源性标记物进行量化外，还对小鼠进行了最大限度的体内功能测试。测试结果各组的日跑步距离（p=0.17）相似，但 VML 抗纤维化组的周平均跑步距离最大（p创新：以再利用方法转化目前经 FDA 批准的药物的能力对于减轻 VML 的病理生理后果以支持功能恢复至关重要。然而，要了解可行性和疗效，仍需进行基础研究和转化研究。结论早期预防纤维组织沉积有助于改善肌肉质量，并在 VML 损伤后长期保持肌肉力量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advances in wound care Medicine-Emergency Medicine

CiteScore

12.10

自引率

4.10%

发文量

期刊介绍： Advances in Wound Care rapidly shares research from bench to bedside, with wound care applications for burns, major trauma, blast injuries, surgery, and diabetic ulcers. The Journal provides a critical, peer-reviewed forum for the field of tissue injury and repair, with an emphasis on acute and chronic wounds. Advances in Wound Care explores novel research approaches and practices to deliver the latest scientific discoveries and developments. Advances in Wound Care coverage includes: Skin bioengineering, Skin and tissue regeneration, Acute, chronic, and complex wounds, Dressings, Anti-scar strategies, Inflammation, Burns and healing, Biofilm, Oxygen and angiogenesis, Critical limb ischemia, Military wound care, New devices and technologies.