细胞因子风暴综合征的免疫学：自然杀伤细胞

4区医学 Q2 Biochemistry, Genetics and Molecular Biology

Advances in experimental medicine and biology Pub Date : 2024-01-01 DOI:10.1007/978-3-031-59815-9_11

Anthony R French, Randy Q Cron, Megan A Cooper

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引用次数: 0

摘要

自然杀伤（NK）细胞是一种先天性免疫淋巴细胞，激活后可迅速产生细胞因子并杀死靶细胞。NK细胞在原发性嗜血细胞淋巴组织细胞增多症（pHLH）中尤其受到关注，因为与该疾病相关的所有基因缺陷都会导致NK细胞和T淋巴细胞的细胞毒能力减弱，而NK细胞杀伤力的检测方法在临床上被用于诊断HLH。在此，我们回顾了人类 NK 细胞生物学以及 NK 细胞功能改变在 HLH 诊断和发病机制中的意义。

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Immunology of Cytokine Storm Syndromes: Natural Killer Cells.

Natural killer (NK) cells are innate immune lymphocytes that rapidly produce cytokines upon activation and kill target cells. NK cells have been of particular interest in primary hemophagocytic lymphohistiocytosis (pHLH) since all of the genetic defects associated with this disorder cause diminished cytotoxic capacity of NK cells and T lymphocytes, and assays of NK cell killing are used clinically for the diagnosis of HLH. Herein, we review human NK cell biology and the significance of alterations in NK cell function in the diagnosis and pathogenesis of HLH.

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来源期刊

Advances in experimental medicine and biology 医学-医学：研究与实验

CiteScore

5.90

自引率

0.00%

发文量

465

审稿时长

2-4 weeks

期刊介绍： Advances in Experimental Medicine and Biology provides a platform for scientific contributions in the main disciplines of the biomedicine and the life sciences. This series publishes thematic volumes on contemporary research in the areas of microbiology, immunology, neurosciences, biochemistry, biomedical engineering, genetics, physiology, and cancer research. Covering emerging topics and techniques in basic and clinical science, it brings together clinicians and researchers from various fields.