婴儿的母乳喂养模式与日后自闭症谱系障碍的诊断有关。

IF 5.3 2区 医学 Q1 BEHAVIORAL SCIENCES
Autism Research Pub Date : 2024-08-08 DOI:10.1002/aur.3211
Leena Elbedour, Rewaa Balaum, Einav Alhozyel, Gal Meiri, Dikla Zigdon, Analya Michaelovski, Orly Kerub, Idan Menashe
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引用次数: 0

摘要

母乳喂养具有医疗和发育方面的益处。本研究旨在评估婴儿出生后第一年的营养模式与自闭症谱系障碍(ASD)可能性之间的关系。这项回顾性病例对照研究纳入了 270 名被诊断患有自闭症谱系障碍的儿童(病例)和 500 名与病例在性别、种族和出生日期(± 3 个月)方面匹配的神经正常儿童(对照组)。这两组儿童均来自 2014 年至 2017 年间出生的儿童,以色列南部的母婴健康诊所对他们的发育/营养状况进行了监测。研究采用条件逻辑回归法确定营养模式与 ASD 的独立关联,同时对社会人口学和临床特征进行调整。纯母乳喂养和部分母乳喂养模式均与 ASD 诊断几率下降有关(aOR = 0.221,95%CI = 0.136-0.360; aOR = 0.494,95%CI = 0.328-0.743)。母乳喂养时间超过12个月与较低的ASD几率相关(aOR = 0.418,95%CI = 0.204-0.855),而6个月后开始喂养固体食物比6个月开始喂养固体食物与较高的ASD几率相关(aOR = 2.455,95%CI = 1.116-4.201)。这些研究结果表明,较长时间的纯母乳喂养与随后ASD诊断几率的降低有关,从而重申了产后适当营养对婴儿神经发育的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Breastfeeding patterns in infants are associated with a later diagnosis of autism Spectrum disorder

Breastfeeding patterns in infants are associated with a later diagnosis of autism Spectrum disorder

Breastfeeding is associated with medical and developmental benefits. This study aimed to assess associations between nutritional patterns in the first year of life and the likelihood of autism spectrum disorder (ASD). 270 children diagnosed with ASD (cases) and 500 neurotypical children (controls) matched to cases by sex, ethnicity, and birth date (± 3 months) were included in this retrospective case–control study. Both groups were ascertained from children born between 2014 and 2017 whose development/nutrition were monitored at mother–child health clinics in southern Israel. Conditional logistic regression was used to determine the independent association of nutritional patterns with ASD while adjusting for socio-demographic and clinical characteristics. Both exclusive and partial breastfeeding modes were associated with decreased odds of ASD diagnosis (aOR = 0.221, 95%CI = 0.136–0.360; aOR = 0.494, 95%CI = 0.328–0.743, respectively). A breastfeeding duration of >12 months was associated with lower ASD odds (aOR = 0.418, 95%CI = 0.204–0.855), while the introduction of solids after 6 months of age was associated with higher ASD odds than the introduction of solids at 6 months (aOR = 2.455, 95%CI = 1.116–4.201). These findings suggest that a longer period of exclusive breastfeeding is associated with a subsequent reduced likelihood of ASD diagnosis, thus reiterating the importance of proper post-natal nutrition for infant neurodevelopment.

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来源期刊
Autism Research
Autism Research 医学-行为科学
CiteScore
8.00
自引率
8.50%
发文量
187
审稿时长
>12 weeks
期刊介绍: AUTISM RESEARCH will cover the developmental disorders known as Pervasive Developmental Disorders (or autism spectrum disorders – ASDs). The Journal focuses on basic genetic, neurobiological and psychological mechanisms and how these influence developmental processes in ASDs.
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