用于骨组织的新型可吸收骨蜡的有效性和生物相容性评估。

IF 2.7 4区医学 Q3 CELL & TISSUE ENGINEERING

Tissue engineering. Part C, Methods Pub Date : 2024-08-01 DOI:10.1089/ten.TEC.2024.0144

Rui Wang, Zejian Jin, Jianfeng Gao, Yan Ma, Qianqian Han

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引用次数: 0

摘要

目的：与市售骨蜡相比，确定新型可吸收骨蜡的止血效果和生物相容性：方法：用 18 只小肥尾绵羊模拟胸骨损伤的临床表面出血。方法：用 18 只小肥尾绵羊模拟临床胸骨损伤表面出血，在手术创面上涂抹材料后的一段时间内对止血效果、骨愈合程度、Mirco-CT 和组织病理学进行评估：结果：研究中使用的可吸收骨蜡可立即止血，且不影响骨愈合。组织病理学结果也显示，新材料没有引起任何并发症：结果表明，本研究中使用的新型可吸收骨蜡效果显著，且具有生物相容性。

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Effectiveness and Biocompatibility Evaluation of a Novel Absorbable Bone Wax Used in Bone Tissue.

This study aims to determine the hemostatic effectivity and biocompatibility of a novel absorbable bone wax in comparison with a commercially available product. Eighteen small fat-tail sheep were used to simulate clinical surface bleeding of sternal injury. Hemostasis effectiveness, the degree of bone healing, micro-computed tomography, and histopathology were evaluated over a period after the application of the material to the surgically created wound. The absorbable bone wax used in the study stopped bleeding immediately and did not affect bone healing. The histopathological results also showed that there were no complications associated with the new material. The results showed that the new absorbable bone wax used in this study was effective and biocompatible.

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来源期刊

Tissue engineering. Part C, Methods Medicine-Medicine (miscellaneous)

CiteScore

5.10

自引率

3.30%

发文量

136

期刊介绍： Tissue Engineering is the preeminent, biomedical journal advancing the field with cutting-edge research and applications that repair or regenerate portions or whole tissues. This multidisciplinary journal brings together the principles of engineering and life sciences in the creation of artificial tissues and regenerative medicine. Tissue Engineering is divided into three parts, providing a central forum for groundbreaking scientific research and developments of clinical applications from leading experts in the field that will enable the functional replacement of tissues. Tissue Engineering Methods (Part C) presents innovative tools and assays in scaffold development, stem cells and biologically active molecules to advance the field and to support clinical translation. Part C publishes monthly.