揭示人乳头瘤病毒与系统性红斑狼疮之间的关联:双向双样本孟德尔随机研究

IF 2 4区 医学 Q3 DERMATOLOGY
Fangfang Pan, Huiliang Shen, Ben Wang, Jian Wang
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引用次数: 0

摘要

背景:越来越多的研究关注人乳头瘤病毒(HPV)感染与系统性红斑狼疮(SLE)之间的关系。然而,目前的证据主要基于回顾性研究,这些研究容易受到干扰因素的影响,无法确定因果关系:方法:采用双向双样本孟德尔随机化(MR)设计来评估人乳头瘤病毒与系统性红斑狼疮之间的因果关系。从HPV暴露数据集中选取了在全基因组关联研究(GWAS)中证据确凿的单核苷酸聚合物(SNPS),并将其作为本研究的工具变量(IV)。对于 MR 分析结果,使用 MR-Egger 截距 P 检验、MR-Presso 全局检验、CochranQ 检验和 leave-one 检验进行敏感性分析:根据 MR 分析的证据,本研究最终确定 HPV16 和 HPV18 与系统性红斑狼疮之间不存在因果关系:结论:HPV感染的可能调节与系统性红斑狼疮的调节并无明显关联。这些发现为了解 HPV 与系统性红斑狼疮的内在机制提供了新的视角,还需要进一步的研究加以验证。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Revealing an association between HPV and systemic lupus erythematosus: A bidirectional two-sample Mendelian randomization study.

Background: An increasing number of studies have focused on the association between Human papillomavirus (HPV) infection and systemic lupus erythematosus (SLE). However, current evidence is largely based on retrospective studies, which are susceptible to confounding factors and cannot establish causation.

Methods: A bidirectional two-sample Mendelian randomization (MR) design was used to evaluate the causal relationship between HPV and SLE. Mononucleoside polymers (SNPS) with strong evidence for genome-wide association studies (GWAS) were selected from the HPV exposure dataset and used as an instrumental variable (IV) for this study. For the MR Analysis results, the MR-Egger intercept P test, MR-Presso global test, CochranQ test and leave-one test were used for sensitivity analysis.

Results: Based on the evidence of MR Analysis, this study finally determined that there was no causal association between HPV16 and HPV18 and SLE.

Conclusions: Possible regulation of HPV infection is not significantly associated with regulation of SLE. These findings provide new insights into the underlying mechanisms of HPV and SLE and need to be validated by further studies.

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来源期刊
Skin Research and Technology
Skin Research and Technology 医学-皮肤病学
CiteScore
3.30
自引率
9.10%
发文量
95
审稿时长
6-12 weeks
期刊介绍: Skin Research and Technology is a clinically-oriented journal on biophysical methods and imaging techniques and how they are used in dermatology, cosmetology and plastic surgery for noninvasive quantification of skin structure and functions. Papers are invited on the development and validation of methods and their application in the characterization of diseased, abnormal and normal skin. Topics include blood flow, colorimetry, thermography, evaporimetry, epidermal humidity, desquamation, profilometry, skin mechanics, epiluminiscence microscopy, high-frequency ultrasonography, confocal microscopy, digital imaging, image analysis and computerized evaluation and magnetic resonance. Noninvasive biochemical methods (such as lipids, keratin and tissue water) and the instrumental evaluation of cytological and histological samples are also covered. The journal has a wide scope and aims to link scientists, clinical researchers and technicians through original articles, communications, editorials and commentaries, letters, reviews, announcements and news. Contributions should be clear, experimentally sound and novel.
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