急性风湿热患儿的赛登哈姆舞蹈症:伊朗西北部儿科患者超声心动图调查。

IF 1.6 Q2 MEDICINE, GENERAL & INTERNAL
Ahmad Jamei Khosroshahi, Vida Kahani, Milad Shirvaliloo, Shahram Sadeghvand
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引用次数: 0

摘要

背景:急性风湿热(ARF)患儿继发于 A 组链球菌感染后,基底节受到损伤,可能会出现叙登罕舞蹈症(SC),但这种情况并不常见。SC的某些特征,如运动障碍,可作为心脏炎的预测指标。本研究旨在调查 ARF 后疑似 SC 儿童的神经和心脏症状:方法:2009 年至 2022 年期间,伊朗大不里士市沙希德-马达尼儿科医院收治了初步诊断为 ARF 和 SC 的所有 5-16 岁儿童,对他们进行超声心动图评估,并在起始点后 6 个月和 12 个月内进行前瞻性随访。瓣膜病变的模式和严重程度以及琼斯风湿热标准的患病率用于评估效果。收集到的数据使用 SPSS 统计软件(22.0 版)进行分析,并进行了卡方检验和费雪精确检验。结果研究共招募了 85 名儿童,其中女孩 36 名,男孩 49 名,平均年龄(9.7±2.7)岁。在首次超声心动图检查中,42.4%的患者患有二尖瓣反流(MR),其中女性患者居多(P=0.04)。在确诊为二尖瓣反流的患者中(12 名女孩和 6 名男孩),66.7% 的患者心脏受累,男女患者中二尖瓣反流的发生率均较高(P=0.04)。6 个月后,两组患者的心脏受累模式有显著差异(P=0.04)。然而,在一年的随访中没有观察到这种差异(P=0.07)。女性性别与 SC 定位有明显关系(P=0.01):结论:除神经系统表现外,SC 还可能伴有临床或亚临床心脏瓣膜功能障碍,且可能持续一年以上。除了尝试早期发现和适当处理外,还建议在入院和随访期间进行精确的心脏和神经系统评估。本手稿的预印版可在以下网站获取:DOI: 10.21203/rs.3.rs-772662/v1(https://www.researchsquare.com/article/rs-772662/v1)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Sydenham's Chorea in Children with Acute Rheumatic Fever: An Echocardiographic Survey of Pediatric Patients in Northwestern Iran.

Background: Although infrequent, Sydenham's chorea (SC) may occur as a result of injury to the basal ganglia in children with acute rheumatic fever (ARF) secondary to group A Streptococcal infection. Certain hallmarks of SC, such as movement disorders, could be utilized as a predictive marker for carditis. The present study aimed to investigate neurologic and cardiologic symptoms in children with suspected SC after ARF.

Methods: All children aged 5-16 who were admitted at Shahid Madani Pediatric Hospital (Tabriz, Iran), with an initial diagnosis of ARF and SC between 2009 and 2022 were included for echocardiographic assessment and prospective follow-up within 6 and 12 months after the start point. The pattern and severity of valvulopathy, as well as the prevalence of Jones criteria for rheumatic fever, were used to assess the effect. The collected data were analyzed using SPSS Statistics software (version 22.0) using Chi square and Fisher's exact tests. P<0.05 was considered statistically significant.

Results: The study enrolled 85 children, 36 girls and 49 boys, with a mean age of 9.7±2.7. On the first echocardiography, 42.4% of patients had mitral valve regurgitation (MR), with a predominance of female patients (P=0.04). Of those diagnosed with SC (12 girls and 6 boys), 66.7% showed cardiac involvement, with a higher prevalence of MR in both sexes (P=0.04). The pattern of cardiac involvement after 6 months was significantly different between the groups (P=0.04). However, no such difference was observed during the one-year follow-up (P=0.07). Female sex was found to have a significant relationship with SC localization (P=0.01).

Conclusion: In addition to its neurological manifestations, SC can be associated with clinical or subclinical cardiac valve dysfunction that might last for more than a year. In addition to attempting early detection and appropriate management, a precise cardiac and neurologic assessment during admission and follow-up is recommended.A preprint version of this manuscript is available at DOI: 10.21203/rs.3.rs-772662/v1 (https://www.researchsquare.com/article/rs-772662/v1).

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来源期刊
Iranian Journal of Medical Sciences
Iranian Journal of Medical Sciences MEDICINE, GENERAL & INTERNAL-
CiteScore
3.20
自引率
0.00%
发文量
84
审稿时长
12 weeks
期刊介绍: The Iranian Journal of Medical Sciences (IJMS) is an international quarterly biomedical publication, which is sponsored by Shiraz University of Medical Sciences. The IJMS intends to provide a scientific medium of com­muni­cation for researchers throughout the globe. The journal welcomes original clinical articles as well as clinically oriented basic science re­search experiences on prevalent diseases in the region and analysis of various regional problems.
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