利用环阵列超声波换能器产生和监测轻度热疗。

IF 3 3区 医学 Q2 ONCOLOGY
International Journal of Hyperthermia Pub Date : 2024-01-01 Epub Date: 2024-08-07 DOI:10.1080/02656736.2024.2376681
David Bustamante, Yan Yan, Trevor Mitcham, Rehman Ali, Brian Marples, Kimberly R Gergelis, Peter Littrup, Nebojsa Duric, Mohammad Mehrmohammadi
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引用次数: 0

摘要

目的证明在超声断层扫描(UST)引导下使用环阵列超声(US)换能器产生和监测温和热疗(MHTh)的可行性:方法:设计了硅学和体外实验来评估环阵列超声换能器在产生温和热疗和监测温度变化方面的功效。在一系列硅学研究中,我们比较了环阵列 US 声换能器在不同频率下产生的声焦谱,并进一步研究了 UST 导向在进行像差校正以增强焦谱方面的有效性。体外实验评估了使用环形阵US换能器产生和维持MHTh的能力,以及使用UST监测温度变化的准确性:模拟结果表明,环阵列 US 声换能器可实现对称和局部声聚焦。在异质组织模型中,环形阵UST换能器在UST的引导下进行像差校正,实现了卓越的声聚焦。体外实验证明,环形阵UST换能器能在平均117±18秒的时间内在组织模拟模型中产生MHTh,并随后保持MHTh。最后,环阵列 US 声纳换能器利用 UST 跟踪预热充水包涵体的温度变化,当包涵体从 45 °C 被动冷却到 25 °C 时,最大误差为 0.58 °C:环阵列 US 传感器可以无创生成和监测 MHTh,克服了当前临床系统的许多局限性。换能器的封闭几何形状是声聚焦的最佳选择,UST 导向可改善异质介质中的像差校正。将 UST 测温与相同的环形阵列 US 换能器结合使用,可实现图像引导、温度控制、全声学 MHTh 系统。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Generating and monitoring mild hyperthermia using a ring array ultrasound transducer.

Objective: To demonstrate the feasibility of using a ring array ultrasound (US) transducer, guided by ultrasound tomography (UST), for generating and monitoring mild hyperthermia (MHTh).

Methods: In silico and in vitro experiments were designed to evaluate the efficacy of a ring array US transducer for generating MHTh and monitoring changes in temperature. In a series of in silico studies, we compared the acoustic focal profiles produced by a ring array US transducer transmitting at different frequencies and further investigated the effectiveness of UST-guidance in implementing aberration correction to enhance the focal profile. In vitro experiments evaluated the capability of using a ring array US transducer to generate and maintain MHTh and the accuracy of using UST to monitor temperature changes.

Results: The simulations demonstrated that a ring array US transducer achieves symmetrical and localized acoustic focusing. In a heterogenous tissue model, a ring array US transducer achieved a superior acoustic focus by implementing aberration correction with guidance from UST. In vitro experiments demonstrated the capability of a ring array US transducer to generate MHTh in a tissue-mimicking phantom in an average of 117 ± 18 s and subsequently maintain MHTh. Lastly, a ring array US transducer utilized UST to track temperature changes in a preheated water-filled inclusion while it passively cooled from 45 °C to 25 °C, with a maximum error of 0.58 °C.

Conclusion: A ring array US transducer can noninvasively generate and monitor MHTh, overcoming many limitations of current clinical systems. The closed geometry of the transducer is optimal for acoustic focusing and UST-guidance allows for improved aberration correction in a heterogenous medium. Utilizing UST thermometry with the same ring array US transducer will allow for implementing an image-guided, temperature-controlled, all-acoustic MHTh system.

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来源期刊
CiteScore
5.90
自引率
12.90%
发文量
153
审稿时长
6-12 weeks
期刊介绍: The International Journal of Hyperthermia
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